| Overall and subgroup analysis | Studies | Test of association | Test of association |
|---|
| OR(95%CI) | P-value | I2 | Ph |
|---|
| S vs. L |
| Total | 5 | 1.31 (1.07–1.60) | 0.008 | 63% | 0.03 |
| Asian | 4 | 1.33 (1.03–1.72) | 0.03 | 72% | 0.01 |
| White | 1 | 1.30 (0.98–1.72) | 0.07 | NA | NA |
| Major depressive disorder | 2 | 1.29 (0.86–1.94) | 0.22 | 79% | 0.03 |
| SS vs. LL |
| Total | 5 | 1.73 (1.12–2.67) | 0.01 | 53% | 0.08 |
| Asian | 4 | 1.75 (0.97–3.13) | 0.06 | 65% | 0.04 |
| White | 1 | 1.67 (0.91–3.07) | 0.10 | NA | NA |
| Major depressive disorder | 2 | 1.67 (0.58–4.83) | 0.34 | 76% | 0.04 |
| LS vs. LL |
| Total | 5 | 1.47 (1.13–1.92) | 0.005 | 40% | 0.15 |
| Asian | 4 | 1.27 (0.77–2.10) | 0.35 | 51% | 0.11 |
| White | 1 | 1.71 (1.06–2.75) | 0.03 | NA | NA |
| Major depressive disorder | 2 | 1.43 (1.01, 2.02) | 0.04 | 0% | 0.41 |
| LS + SS vs. LL |
| Total | 5 | 1.62 (1.25–2.09) | 0.0002 | 38% | 0.17 |
| Asian | 4 | 1.52 (0.93–2.47) | 0.09 | 53% | 0.09 |
| White | 1 | 1.70 (1.07–2.69) | 0.02 | NA | NA |
| Major depressive disorder | 2 | 1.62 (0.79–3.30) | 0.19 | 56% | 0.13 |
| SS vs. LL + LS |
| Total | 5 | 1.33 (1.02–1.74) | 0.03 | 62% | 0.03 |
| Asian | 4 | 1.39 (1.01–1.91) | 0.05 | 71% | 0.02 |
| White | 1 | 1.17 (0.70–1.96) | 0.54 | NA | NA |
| Major depressive disorder | 2 | 1.21 (0.66–2.22) | 0.54 | 80% | 0.03 |
- OR odds ratio, CI confidence intervals, NA not applicable
