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Fig. 5 | BMC Cardiovascular Disorders

Fig. 5

From: Recombinant Klotho protein enhances cholesterol efflux of THP-1 macrophage-derived foam cells via suppressing Wnt/β-catenin signaling pathway

Fig. 5

Effect of recombinant Klotho on Wnt/β-catenin signaling pathway. a Screening of the optimal concentration of foam cells by Wnt/β-catenin signaling pathway inhibitor DKK1. b Oil red O staining (400×); c Total cholesterol level assay; d mRNA level expression of cholesterol metabolism-related genes (ABCA1, ABCG1, ACAT1, CD36 and SRA1); e/f Expression of cholesterol metabolism related proteins (ABCA1, ABCG1, ACAT1, CD36 and SRA1). Con, Control group; Re-KL, recombinant Klotho group; PMA, phorbol myristate acetate; ox-LDL, oxidized low-density lipoprotein; DKK1, dickkopf-related protein 1. **P < 0.01 vs. control group; #P < 0.05 and ##P < 0.01 vs. model (ox-LDL) group; &P < 0.05 and &&P < 0.01 vs. DKK1 (ox-LDL + DKK1) group

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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