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Table 2 Primary and secondary endpoints for the QUEST STEMI study

From: Rationale and design of a prospective, observational study for the QUantitative EStimation of Thrombus burden in patients with ST-Elevation Myocardial Infarction using micro-computed tomography: the QUEST-STEMI trial

Primary endpoints
• Volume of aspirated thrombus burden (in mm3)
• Density of aspirated thrombus burden (in Housefield Units)
Secondary endpoints
• Association between extracted thrombus volume/thrombus density and factors from patients’ medical history (diabetes mellitus, use of antiplatelet drugs or anticoagulants, pain-to-balloon time and history of smoking)
• Correlation of the volume/density of aspirated thrombus burden with the Sianos’ classification of thrombus burden [19]
• Association between extracted thrombus volume/density and ST-segment resolution. ST resolution will be classified as complete (> 70%), partial (30–70%), or absent (< 30%) [28]
• Association between extracted thrombus volume/density and post-procedural Thrombolysis in Myocardial Infarction (TIMI) flow
• Association between extracted thrombus volume/density and distal embolization
• Association between extracted thrombus volume/density and myocardial blush grade
• Association between extracted thrombus volume and angiographically evident residual thrombus burden
• Association between extracted thrombus volume/density and the device used for thrombus aspiration
• Association between extracted thrombus volume/density with MACCE (acute myocardial infarction, stent thrombosis, target lesion revascularization, cardiac death, cerebrovascular death, or stroke) at 12 months follow-up