Table 2 Primary and secondary endpoints for the QUEST STEMI study

Primary endpoints

• Volume of aspirated thrombus burden (in mm³)

• Density of aspirated thrombus burden (in Housefield Units)

Secondary endpoints

• Association between extracted thrombus volume/thrombus density and factors from patients’ medical history (diabetes mellitus, use of antiplatelet drugs or anticoagulants, pain-to-balloon time and history of smoking)

• Correlation of the volume/density of aspirated thrombus burden with the Sianos’ classification of thrombus burden [19]

• Association between extracted thrombus volume/density and ST-segment resolution. ST resolution will be classified as complete (> 70%), partial (30–70%), or absent (< 30%) [28]

• Association between extracted thrombus volume/density and post-procedural Thrombolysis in Myocardial Infarction (TIMI) flow

• Association between extracted thrombus volume/density and distal embolization

• Association between extracted thrombus volume/density and myocardial blush grade

• Association between extracted thrombus volume and angiographically evident residual thrombus burden

• Association between extracted thrombus volume/density and the device used for thrombus aspiration

• Association between extracted thrombus volume/density with MACCE (acute myocardial infarction, stent thrombosis, target lesion revascularization, cardiac death, cerebrovascular death, or stroke) at 12 months follow-up