Fig. 1

Genetic analysis and in silico prediction. a A heterozygous frame-shift variant DSP c.832delG was identified through targeted next generation sequencing; b Pedigree and genotype. Family members in the red frame were genotyped. Arrow indicates the proband; squares indicate male family members; circles indicate female members; black filled indicate family members diagnosed with AC or experienced sudden cardiac death; diagonal lines indicate deceased family member; c Schematic diagram of the location of DSP p.A278Pfs*39