Table 2 Comparison of clinical and laboratory parameters of participants according to MC4R rs17782313 genotypes
| Â | Women | Men | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
TT | TC | CC | P* | P** | TT | TC | CC | P* | P** | |
LDL-C, (mg/dl) | 126.9 (29.60) | 118.56 (31.06) | 108.91 (28.09) | 0.161 | 0.153 | 120.46 (26.31) | 118.30 (30.01) | 108.58 (28.41) | 0.471 | 0.533 |
HDL, (mg/dl) | 48.46 (10.27) | 46.37 (10.19) | 49.44 (6.46) | 0.549 | 0.720 | 41.11 (6.64) | 43.35 (9.22) | 44.45 (9.61) | 0.388 | 0.421 |
Cholesterol, (mg/dl) | 197.71 (33.88) | 185.74 (35.45) | 177.75 (28.62) | 0.146 | 0.120 | 188.4 (28.39) | 187.78 (31.20) | 184.09 (43.36) | 0.918 | 0.953 |
TG, (mg/dl) | 111.75 (46.33) | 104.07 (41.84) | 97 (35.23) | 0.530 | 0.430 | 122 (80, 169) | 121 (90, 164) | 123 (90, 184) | 0.931 | 0.873 |
AIP | −0.0226 (0.240) | −0.032 (0.230) | −0.087 (0.175) | 0.631 | 0.608 | 0.11(0.23) | 0.09 (0.25) | 0.12 (0.29) | 0.907 | 0.866 |
Glucose, (mg/dl) | 92.00 (87.25, 97.00) | 91 (81, 101) | 90.00 (85.25, 94.00) | 0.834 | 0.675 | 93 (87, 102) | 90 (83, 97) | 100 (87, 159) | 0.016 | 0.012 |
Insulin, U/mL | 13.55 (9.28, 24.10) | 19.60 (9.70, 27.30) | 13.75 (9.00, 16.23) | 0.306 | 0.278 | 11.40 (8.90, 17.20) | 10.90 (8.40, 19.50) | 11.00 (9.30, 24.80) | 0.507 | 0.439 |
HOMA-IRa | 3.17 (2.00, 5.56) | 4.82 (2.01, 6.58) | 3.15 (2.09, 3.56) | 0.409 | 0.395 | 2.70 (1.78, 4.13) | 2.61 (1.87, 5.04) | 4.16 (2.30, 6.70) | 0.077 | 0.061 |
QUICKI | 0.32 (0.03) | 0.32 (0.04) | 0.33 (0.03) | 0.466 | 0.345 | 0.33 (0.03) | 0.33 (0.03) | 0.31 (0.03) | 0.126 | 0.104 |
SBP (mmHg) | 111.86(14.48) | 116.64 (16.85) | 111.19 (14.40) | 0.404 | 0.716 | 117.71 (12.45) | 118.70 (15.83) | 115.4 (13.68) | 0.816 | 0.966 |
DBP (mmHg) | 76.5 (10.11) | 78.82 (14.38) | 75.5 (11.68) | 0.644 | 0.810 | 77 (10.79) | 78.26 (10.93) | 74.09 (11.36) | 0.584 | 0.664 |
α-MSH (ng/L) | 2.16 (2.12–2.20) | 2.26 (2.17–2.35) | 2.26 (2.11–2.41) | 0.153 | 0.259 | 2.29 (2.20–2.37) | 2.39 (2.25–2.52) | 2.18 (2.09–2.27) | 0.105 | 0.175 |
AgRP (pg/ml) | 1.33 (1.29–1.37) | 1.43 (1.36–1.51) | 1.41 (1.29–1.53) | 0.082 | 0.176 | 1.49 (1.42–1.57) | 1.57 (1.46–1.68) | 1.33 (1.25–1.41) | 0.025 | 0.046 |