Skip to main content

Table 3 Association of cumulative social risk with risk of combined all-cause mortality or CVD outcomes, with adjustment for a) traditional CVD risk factors, b) further adjustment for PM2.5 or BC in mediation analyses. (N = 1622, N cases = 137)

From: Association between cumulative social risk, particulate matter environmental pollutant exposure, and cardiovascular disease risk

a) Traditional CVD risk factors

 

CSR = 1 vs. CSR = 0

CSR ≥ 2 vs. CSR = 0

Test for trend

 Adjustment

HR (95% CI)

Chi-2

HR (95% CI)

Chi-2

HR (95% CI)

Chi-2

 Age & sex

1.67 (1.06,2.63)

4.80

2.85(1.84,4.40)

22.28

1.69(1.36,2.10)

22.75

 Model 1

1.68 (1.06,2.65)

4.93

2.60(1.67,4.04)

18.06

1.61(1.29,2.00)

18.40

 Model 2

1.66(1.05,2.62)

4.67

2.45(1.57,3.82)

15.60

1.56(1.25,1.94)

15.84

 Model 3

1.56(0.99,2.48)

3.65

2.20(1.40,3.45)

11.83

1.48(1.18,1.84)

11.97

 Model 4

1.57(0.99,2.48)

3.69

2.24(1.42,3.52)

12.04

1.49(1.19,1.86)

12.18

 Full Model

1.59(1.01,2.52)

3.96

2.34(1.48,3.68)

13.32

1.52(1.22,1.91)

13.47

b) Mediation analyses

 Full Model + PM2.5

1.54(0.97,2.45)

3.35

2.16(1.34,3.49)

9.92

1.47(1.16,1.86)

10.05

 Full Model + BC

1.56(0.99,2.48)

3.61

2.25(1.42,3.58)

11.90

1.50(1.19,1.88)

12.04

  1. Model 1 = Age & Sex + Smoking
  2. Model 2 = Model 1 + SBP
  3. Model 3 = Model 2 + Diabetes
  4. Model 4 = Model 3 + BMI
  5. Full Model = Model 4 + lipid markers (total cholesterol, HDL-c, TG)
  6. The degree of attenuation in the association between CSR and risk of combined all-cause mortality and CVD outcomes when adjusting for PM2.5 was comparable to the effect of adjustment for SBP
  7. Mediation analyses indicate that PM2.5 explained 13% of the relative risk of CVD and all cause mortality in individuals with CSR score ≥ 2 (compared to those with CSR score = 0). The corresponding value for BC was 7%
Back to article page

BMC Cardiovascular Disorders

ISSN: 1471-2261

Contact us