Serum amyloid a protein as a potential biomarker in predicting acute onset and association with in-hospital death in acute aortic dissection

He, Yuchen; Ma, Changcheng; Xing, Jia; Wang, Shiyue; Ji, Chao; Han, Yanshuo; Zhang, Jian

doi:10.1186/s12872-019-1267-0

Table 3 Comparisons of blood parameters between different sub-groups in AAD patient group

From: Serum amyloid a protein as a potential biomarker in predicting acute onset and association with in-hospital death in acute aortic dissection

Parameters	TAAD	TBAD	P value	less than 6 h	more than 6 h	P value	communicating false lumen	non-communicating false lumen	P value	Death	Survival	P value
WBC, × 10⁹/L	11.54 ± 4.5	10.06 ± 3.92	0.198	10.73 ± 4.75	10.75 ± 3.78	0.917	12.1 ± 5.8	10.41 ± 3.74	0.522	12.78 ± 4.05	9.96 ± 4.08	0.004
BA/WBC, %	0.20 ± 0.23	0.28 ± 0.34	0.646	0.24 ± 0.3	0.25 ± 0.30	0.723	0.3 ± 0.28	0.23 ± 0.30	0.231	0.22 ± 0.21	0.26 ± 0.32	0.954
EO/WBC, %	1.37 ± 1.65	0.89 ± 1.51	0.139	0.95 ± 1.37	1.26 ± 1.76	0.409	1.04 ± 1.34	1.13 ± 1.65	0.783	0.66 ± 1.06	1.28 ± 1.72	0.039*
MO/WBC, %	13.29 ± 14.10	8.48 ± 9.03	0.002**	9.29 ± 7.37	11.96 ± 14.7	0.909	15.02 ± 19.28	9.63 ± 9.04	0.648	9.21 ± 9.16	11.26 ± 12.71	0.227
LY/WBC, %	14.87 ± 9.26	15.98 ± 9.1	0.462	14.76 ± 8.5	16.1 ± 9.72	0.596	14.24 ± 8.78	15.77 ± 9.26	0.514	11.62 ± 5.68	16.94 ± 9.79	0.043*
NE/WBC, %	69.92 ± 15.24	74.31 ± 12.97	0.198	74.49 ± 12.41	70.31 ± 15.41	0.275	69.4 ± 18.71	73 ± 12.86	0.638	77.88 ± 10.9	70.15 ± 14.72	0.017*
RBC, × 10¹²/L	4.26 ± 0.64	4.52 ± 0.76	0.014*	4.36 ± 0.65	4.43 ± 0.77	0.730	4.32 ± 0.80	4.42 ± 0.69	0.523	4.46 ± 0.82	4.38 ± 0.68	0.582
HGB, g/L	128.63 ± 17.86	135.61 ± 23.03	0.052	134.92 ± 18.44	130.13 ± 23	0.328	126.73 ± 27.9	133.79 ± 18.92	0.497	131.19 ± 25.29	132.85 ± 19.31	0.968
MCH, pg	30.45 ± 3.12	30.49 ± 1.94	0.373	31.06 ± 2.15	29.94 ± 2.75	0.015*	29.89 ± 4.59	30.61 ± 1.73	0.958	29.68 ± 3.41	30.77 ± 2.07	0.104
MCV, fL	91.66 ± 8.00	92.11 ± 5.52	0.696	93.2 ± 5.67	90.74 ± 7.43	0.181	90.10 ± 11.44	92.35 ± 5.01	0.681	89.83 ± 9.28	92.69 ± 5.36	0.168
MCHC, g/L	331.77 ± 11.11	331.12 ± 11.83	0.731	333.17 ± 9.78	329.85 ± 12.65	0.348	330.8 ± 17.09	331.57 ± 9.75	0.445	329.81 ± 11.29	332.04 ± 11.53	0.183
HCT, L/L	0.38 ± 0.06	0.41 ± 0.07	0.083	0.41 ± 0.06	0.39 ± 0.08	0.428	0.38 ± 0.09	0.40 ± 0.06	0.567	0.39 ± 0.08	0.40 ± 0.06	0.802
RDW, %	13.73 ± 2.43	13.25 ± 1.3	0.864	13.38 ± 1.47	13.51 ± 2.17	0.753	14.26 ± 2.64	13.25 ± 1.59	0.253	13.74 ± 1.78	13.33 ± 1.89	0.089
PLT, ×10⁹/L	199.34 ± 67.05	183.12 ± 69	0.196	177.75 ± 64.26	202.15 ± 70.25	0.218	166.07 ± 62.69	196.62 ± 68.56	0.168	182.33 ± 59.6	193.75 ± 71.4	0.597
MPV, fL	9.48 ± 1.13	9.93 ± 1.67	0.158	9.95 ± 1.43	9.52 ± 1.46	0.380	9.51 ± 1.77	9.77 ± 1.39	0.675	9.91 ± 1.06	9.65 ± 1.58	0.480
PCT, L/L	1.02 ± 2.26	0.36 ± 1.11	0.076	0.80 ± 1.99	0.56 ± 1.54	0.264	1.22 ± 2.57	0.55 ± 1.52	0.670	0.87 ± 2.10	0.59 ± 1.62	0.472
PDW, 10GSD	14.51 ± 2.72	14.4 ± 2.90	0.657	14.9 ± 3.00	14.06 ± 2.59	0.260	15.26 ± 2.12	14.27 ± 2.91	0.308	14.51 ± 2.53	14.42 ± 2.92	0.489
TP, g/L	63.93 ± 7.68	63.78 ± 10.34	0.540	64.76 ± 8.76	63.05 ± 9.56	0.410	61.72 ± 9.1	64.38 ± 9.19	0.277	62.27 ± 10.19	64.46 ± 8.77	0.591
PA, mg/dL	15.96 ± 6.67	17.71 ± 6.29	0.231	14.18 ± 6.55	18.88 ± 5.74	0.005**	16.94 ± 6.67	16.78 ± 6.52	0.868	14.75 ± 5.06	17.56 ± 6.83	0.177
ALB, g/L	35.75 ± 6.12	36.84 ± 6.93	0.341	37.03 ± 6.36	35.75 ± 6.74	0.470	34.45 ± 7.3	36.82 ± 6.34	0.185	36.63 ± 7.29	36.23 ± 6.32	0.813
ALP, U/L	106.79 ± 81.75	99.61 ± 43.41	0.583	104.84 ± 59.66	100.79 ± 66.18	0.793	102.42 ± 62.94	102.83 ± 63.19	0.925	103 ± 59.7	102.66 ± 64.29	0.773
ALT, U/L	140.94 ± 407.11	57.24 ± 61.02	0.151	91.74 ± 203.78	98.2 ± 333.43	0.210	119.07 ± 305.66	89.22 ± 274.01	0.408	147.86 ± 454.6	74.7 ± 170.15	0.224
AST, U/L	94 ± 364.89	60.56 ± 101.49	0.249	59.69 ± 101.85	91.36 ± 346.71	0.502	43.86 ± 45.18	83.97 ± 288.02	0.709	170.45 ± 488.11	41.54 ± 56.58	0.123
GGT, U/L	128.38 ± 212.94	94.02 ± 122.55	0.766	139.77 ± 181.81	83.2 ± 154.87	0.057	127.2 ± 192.56	105.2 ± 164.37	0.942	99.95 ± 158.57	113.35 ± 174.47	0.402
CHE, 1000 U/L	6.02 ± 1.65	5.96 ± 1.71	0.666	5.70 ± 1.54	6.22 ± 1.74	0.247	5.48 ± 1.68	6.13 ± 1.65	0.273	5.83 ± 1.54	6.05 ± 1.72	0.599
TBA, μmol/L	4.76 ± 4.87	4.16 ± 5.86	0.312	5.84 ± 7.11	3.36 ± 2.95	0.170	4.19 ± 3.29	4.54 ± 5.79	0.873	3.15 ± 2.67	4.95 ± 5.97	0.415
DBIL, μmol/L	8.93 ± 9.78	5.77 ± 2.84	0.493	9.7 ± 10.4	5.66 ± 3.36	0.122	8.72 ± 7.26	7.31 ± 8.06	0.463	6.58 ± 3.14	7.95 ± 8.77	0.815
TBIL, μmol/L	17.95 ± 14.17	16.75 ± 8.70	0.568	20.2 ± 14.67	14.81 ± 6.88	0.103	18.37 ± 10.52	17.01 ± 11.68	0.389	16.06 ± 8.68	17.74 ± 12.29	0.742
CK, U/L	186.1 ± 220.13	382 ± 1184.96	0.865	217.87 ± 314.36	360.08 ± 1186.69	0.940	287.88 ± 338.95	295.68 ± 974.92	0.122	562.31 ± 1711.62	203.15 ± 288.52	0.645
CKMB, U/L	17.95 ± 9.85	22.39 ± 22.55	0.343	18.16 ± 8.53	21.32 ± 21.17	0.930	18.23 ± 9.23	20.25 ± 17.83	0.914	26.84 ± 28.62	17.31 ± 8.18	0.607
Urea, mmol/L	7.56 ± 3.99	7.94 ± 8.41	0.127	7.84 ± 6.95	7.7 ± 6.56	0.640	8.29 ± 5.08	7.64 ± 7.08	0.296	7.87 ± 4.51	7.73 ± 7.41	0.646
Uric, mmol/L	273.5 ± 159.03	352.75 ± 214.01	0.280	332.93 ± 185.1	277.47 ± 184.43	0.213	314.57 ± 211.96	302.35 ± 179.47	0.623	376.29 ± 204.76	283.57 ± 175.97	0.177
Crea mmol/L	91.22 ± 43.83	111.17 ± 82.2	0.789	110.42 ± 66.54	88.13 ± 55.74	0.083	99.33 ± 70.69	98.91 ± 59.94	0.614	100.3 ± 22.1	98.58 ± 69.99	0.054
CYSC, mg/L	1.30 ± 0.53	1.42 ± 0.95	0.990	1.38 ± 0.79	1.34 ± 0.73	0.654	1.54 ± 0.84	1.32 ± 0.74	0.412	1.35 ± 0.63	1.36 ± 0.81	0.837
C1q, mmol/L	182.2 ± 35.56	200.05 ± 38.89	0.172	177.55 ± 36.91	198.33 ± 35.83	0.074	181.63 ± 33.57	191.32 ± 38.81	0.763	176.91 ± 31.95	191.81 ± 38.46	0.563
Na, mmol/L	138.48 ± 4.85	141.52 ± 6.29	0.037*	140.08 ± 7.12	140.15 ± 4.48	0.731	139.35 ± 8.79	140.3 ± 4.94	0.293	140.66 ± 6.7	139.91 ± 5.53	0.991
K, mmol/L	3.63 ± 0.87	4.27 ± 0.66	0.015*	3.92 ± 0.62	3.84 ± 1.02	0.724	4.18 ± 0.42	3.79 ± 0.91	0.095	3.7 ± 1.14	3.94 ± 0.74	0.274
CL, mmol/L	103.36 ± 5.92	111.18 ± 7.39	0.000***	104.75 ± 8.74	108 ± 5.91	0.052	105.88 ± 11.64	106.56 ± 6.14	0.875	108.57 ± 8.95	105.71 ± 7.01	0.704
HCO₃, mmol/L	24.15 ± 2.41	23.98 ± 2.95	0.767	24.37 ± 2.47	23.76 ± 2.92	0.236	23.71 ± 2.39	24.14 ± 2.79	0.341	22.42 ± 2.71	24.69 ± 2.45	0.011*
PH value	6.93 ± 0.69	6.49 ± 1.08	0.106	7.06 ± 0.6	6.44 ± 1.02	0.021*	6.5 ± 1.04	6.81 ± 0.85	0.915	6.8 ± 0.81	6.73 ± 0.93	0.649
TC, mmol/L	4.19 ± 0.83	4.59 ± 1.17	0.255	4.62 ± 1.32	4.3 ± 0.84	0.589	4.92 ± 1.47	4.32 ± 0.93	0.361	4.51 ± 1.13	4.39 ± 1.03	0.333
TG, mmol/L	1.34 ± 0.56	1.34 ± 0.67	0.834	1.24 ± 0.47	1.41 ± 0.71	0.677	1.5 ± 0.57	1.31 ± 0.63	0.283	1.23 ± 0.44	1.39 ± 0.69	0.664
ApoA1, mmol/L	1.14 ± 0.18	1.21 ± 0.22	0.469	1.18 ± 0.17	1.18 ± 0.22	0.938	1.14 ± 0.31	1.19 ± 0.18	0.776	1.24 ± 0.16	1.14 ± 0.22	0.218
ApoB, mmol/L	0.85 ± 0.22	0.76 ± 0.13	0.674	0.75 ± 0.22	0.83 ± 0.13	0.277	0.85 ± 0.13	0.79 ± 0.18	0.506	0.76 ± 0.2	0.82 ± 0.16	0.425
LDL-C, mmol/L	2.58 ± 0.78	2.87 ± 1.06	0.246	2.87 ± 1.04	2.68 ± 0.92	0.620	3.23 ± 1.00	2.66 ± 0.94	0.133	2.65 ± 1.05	2.81 ± 0.93	0.899
HDL-C, mmol/L	1.08 ± 0.34	1.22 ± 0.31	0.139	1.18 ± 0.25	1.16 ± 0.37	0.649	1.09 ± 0.38	1.19 ± 0.31	0.570	1.25 ± 0.25	1.13 ± 0.35	0.150
LDH, U/L	451.88 ± 779.15	487.03 ± 489.75	0.138	505.85 ± 538.16	444.28 ± 694.87	0.171	410.67 ± 242.15	487.85 ± 692.2	0.645	826.64 ± 1148.14	359 ± 255.33	0.036*
INR	1.14 ± 0.22	1.08 ± 0.11	0.446	1.13 ± 0.21	1.09 ± 0.13	0.172	1.09 ± 0.12	1.11 ± 0.18	0.788	1.18 ± 0.26	1.08 ± 0.10	0.152
PT, s	13.11 ± 2.41	13.28 ± 1.33	0.149	13.51 ± 2.27	12.96 ± 1.51	0.119	12.9 ± 1.57	13.28 ± 1.96	0.634	13.91 ± 2.65	12.89 ± 1.36	0.131
PTA, %	85.87 ± 17.42	89.28 ± 12.04	0.615	85.62 ± 16.02	89.38 ± 13.59	0.198	88.54 ± 13.99	87.53 ± 15.01	0.974	83.4 ± 19.2	89.61 ± 12.04	0.279
APTT, s	32.28 ± 5.28	35.79 ± 5.86	0.008**	34.39 ± 6.11	34.04 ± 5.69	0.948	34.42 ± 6.43	34.14 ± 5.75	0.834	35.4 ± 6.4	33.67 ± 5.57	0.339
FPG, mmol/L	7.61 ± 2.84	6.92 ± 2.05	0.355	7.2 ± 1.92	7.22 ± 2.81	0.281	6.38 ± 1.63	7.45 ± 2.57	0.069	7.90 ± 2.25	6.92 ± 2.46	0.032*
CRP, mg/L	95.73 ± 60.92	70.53 ± 76.14	0.115	90.4 ± 83.01	71.92 ± 61.85	0.597	79.43 ± 84.49	79.81 ± 69.09	0.889	138.21 ± 68.8	48.78 ± 50.86	0.000***
D-Dimer, μg/mL	2.02 ± 3.57	4.10 ± 5.73	0.187	3.25 ± 4.94	3.09 ± 5.02	0.234	1.81 ± 1.69	3.49 ± 5.42	0.759	6.20 ± 6.91	1.83 ± 3.05	0.006**
SAA, mg/L	4.22 ± 0.33	4.58 ± 0.48	0.595	4.61 ± 0.42	4.21 ± 0.45	0.582	5.28 ± 0.81	4.44 ± 0.51	0.416	6.21 ± 0.65	3.78 ± 0.31	0.001***

Note, BMI Body Mass Index, HR heart rate, WBC white blood cells, RBC red blood cells, HGB hemoglobin, PLT Platelet, BA basophil, EO eosinophil, LY lymphocyte, MO monocyte, NE neutrophil, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, MCV mean corpuscular Volume, MPV mean platelet volume, HCT hematocrit, PCT platelet hematocrit, PDW platelet distribution width, RDW red blood cell volume distribution width, APTT activated partial thromboplastin time, PT prothrombin time, PTA prothrombin activity, INR international normalized ratio, CK creatine kinase, CKMB creatine kinase isoenzyme MB, CRP C-reactive protein, ALB albumin, ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, DBIL direct dilirubin, TBIL total bilirubin, CHE cholinesterase, GGT gamma glutamyl transpeptidase, TBA total bile acid, TP total protein, PA pre-albumin, LDH lactate dehydrogenase, Na serum sodium, CL serum chlorine, Crea Creatinine, CYSC Cystatin C, K serum kalium, ApoA1 apolipoprotein A-1, ApoB apolipoprotein B, FPG fasting plasma glucose, HDL-C high-density lipoprotein-cholesterol, TC total cholesterol, TG triglycerides, LDL-C low-density lipoprotein-cholesterol
*P < 0.05; **P < 0.01; ***P < 0.001

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