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Fig. 4 | BMC Cardiovascular Disorders

Fig. 4

From: Apolipoprotein M and sphingosine-1-phosphate complex alleviates TNF-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway

Fig. 4

ApoM-S1P activates PI3K/AKT signaling pathway to attenuate pyroptosis and inflammatory response of HUVECs. Note: The detection of phosphorylation level of PI3K and AKT by Western blot. Data were shown as mean ± SD, **P < 0.001 compared to the Control group, ***P < 0.001 compared to the TNF-α + ApoM group, ***P < 0.001 compared to TNF-α + ApoM+S1P group; HUVECs, human umbilical vein endothelial cells; SD, standard deviation

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