Thromboembolic risks associated with paroxysmal and persistent atrial fibrillation in Asian patients: a report from the Chinese atrial fibrillation registry

Table 2 Thromboembolic outcomes in different groups of atrial fibrillation type stratified by anticoagulant drugs during follow-up

Thromboembolic outcomes	With warfarin/NOAC		HR(95%CI)	P value ^a	Without warfarin/NOAC		HR (95%CI)	P value^a
Thromboembolic outcomes	Total events/n	Incidence rates/100 pt.^ayrs	HR(95%CI)	P value ^a	Total events/n	Incidence rates/100 pt.^ayrs	HR (95%CI)	P value^a
Stroke /TIA/PT
PeAF	51/1804	1.2	0.988	0.955	100/2078	1.9	1.521	0.003
PaAF	37/1359	1.3	(0.647–1.509)		99/3276	1.3	(1.152–2.008)	0.003
Stroke
PeAF	41/1805	1.0	1.014	0.953	72/2078 77/3276	1.4	1.414	0.003
PaAF	29/1360	1.0	(0.633–1.630)			1.0	(1.025–1.950)	0.003
TIA
PeAF	11/1807	0.3	0.988	0.980	33/2079	0.6	2.301	0.003
PaAF	8/1362	0.3	(0.397–2.457)		21/3279	0.3	(1.331–3.977)	0.003
PT
PeAF	2/1808	0.0	0.470	0.408	8/3279	0.1	0.919	0.882
PaAF	3/1363	0.1	(0.078–2.814)		5/2079	0.1	(0.300–2.810)	0.882
Intracranial hemorrhage
PeAF	9/1808	0.2	1.806	0.875	5/2079	0.1	1.059	0.923
PaAF	6/1363	0.2	(0.386–3.054)		7/3278	0.1	(0.336–3.337)	0.923
All-cause death
PeAF	57/1806	1.4	1.242	0.327	201/2068	4.0	3.028	< 0.0001
PaAF	33/1361	1.2	(0.805–1.916)		104/3271	1.3	(2.389–3.836)	< 0.0001
Cardiac death
PeAF	21/1807	0.5	1.603	0.237	101/2073	1.9	4.314	< 0.0001
PaAF	10/1362	0.3	(0.734–3.503)		36/3278	0.5	(2.949–6.312)	< 0.0001
Non-cardiac death
PeAF	30/1808	0.7	1.17	0.599	68/2078 47/3275	1.3	2.18	< 0.0001
PaAF	18/1362	0.6	(0.652–2.099)			0.6	(1.503–3.162)	< 0.0001
Stroke /TIA/PT/all-cause death
PeAF	103/1802	2.6	1.119	0.478	285/2067191/3268	5.9	2.352	< 0.0001
PaAF	66/1357	2.4	(0.820–1.527)			2.5	(1.958–2.825)	< 0.0001

NOAC indicates new oral anticoagulation, HR hazard ratio, CI confidence interval, TIA transient ischemic attack, PT peripheral thromboembolism, PaAF paroxysmal atrial fibrillation, and PeAF persistent atrial fibrillation
^aIncidence rates were compared by Cox proportional hazards regression models, stratified by anticoagulant drugs

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