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Table 4 Hazard Ratios (95% Confidence Intervals) of Atrial Fibrillation by Categories of Blood Pressure According to JNC 7 and 2017 ACC/AHA Definitions, ARIC 1987–2015

From: Association and impact of hypertension defined using the 2017 AHA/ACC guidelines on the risk of atrial fibrillation in The Atherosclerosis Risk in Communities study

JNC 7

Normal

Prehypertension

Hypertension

No. of AF cases

941

724

1226

No. of participants

6249

3619

5047

Person-years

142,742

77,849

98,426

Incidence rate (per 1000 PY)

6.6

9.3

12.5

Model 1 [HR (95%CI)]

1 (ref.)

1.30 (1.17, 1.43)

1.90 (1.73, 2.07)

Model 2 [HR (95%CI)]

1 (ref.)

1.24 (1.12, 1.36)

1.58 (1.44, 1.74)

2017 ACC/AHA

Normal

Elevated

Stage 1

Stage 2

No. of AF cases

941

342

382

1226

No. of participants

6249

1562

2057

5047

Person-years

142,742

33,183

44,666

98,426

Incidence rate (per 1000 PY)

6.6

10.3

8.6

12.5

Model 1 [HR (95%CI)]

1 (ref.)

1.36 (1.20, 1.54)

1.24 (1.10, 1.40)

1.90 (1.73, 2.07)

Model 2 [HR (95%CI)]

1 (ref.)

1.26 (1.11, 1.43)

1.21 (1.07, 1.37)

1.58 (1.44, 1.74)

  1. Model 1: Adjusted for age, sex, and race
  2. Model 2: Adjusted for age, sex, race, height, education, field center, body mass index, smoking, drinking status, diabetes, heart failure, coronary heart disease, and stroke
  3. JNC 7 7th Joint National Committee, ACC/ AHA American College of Cardiology/American Heart Association, PY person-years