TY - JOUR AU - Kappler, Benjamin AU - Ledezma, Carlos A. AU - van Tuijl, Sjoerd AU - Meijborg, Veronique AU - Boukens, Bastiaan J. AU - Ergin, Bülent AU - Tan, P. J. AU - Stijnen, Marco AU - Ince, Can AU - Díaz-Zuccarini, Vanessa AU - de Mol, Bas A. J. M. PY - 2019 DA - 2019/11/11 TI - Investigating the physiology of normothermic ex vivo heart perfusion in an isolated slaughterhouse porcine model used for device testing and training JO - BMC Cardiovascular Disorders SP - 254 VL - 19 IS - 1 AB - The PhysioHeart™ is a mature acute platform, based isolated slaughterhouse hearts and able to validate cardiac devices and techniques in working mode. Despite perfusion, myocardial edema and time-dependent function degradation are reported. Therefore, monitoring several variables is necessary to identify which of these should be controlled to preserve the heart function. This study presents biochemical, electrophysiological and hemodynamic changes in the PhysioHeart™ to understand the pitfalls of ex vivo slaughterhouse heart hemoperfusion. SN - 1471-2261 UR - https://doi.org/10.1186/s12872-019-1242-9 DO - 10.1186/s12872-019-1242-9 ID - Kappler2019 ER -