Variable | Overall (n = 5923) | Low D-dimer group (n = 1975) | Intermediate D-dimer group (n = 1974) | High D-dimer group(n = 1974) | p-value |
---|---|---|---|---|---|
Demographics | |||||
Age, yrs | 62.2 ± 11.3 | 58.4 ± 10.2 | 62.9 ± 10.5 | 65.2 ± 12.1 | <0.001 |
male | 4117 (69.5) | 1495 (75.7) | 1343 (68.0) | 1279 (64.8) | <0.001 |
Medical history | |||||
History of Diabetes Mellitus | 1875 (31.7) | 595 (30.1) | 630 (31.9) | 650 (32.9) | 0.159 |
History of Hypertension | 3517 (59.4) | 1116 (56.5) | 1228 (62.2) | 1173 (59.4) | 0.001 |
History of MI | 563 (9.5) | 169 (8.6) | 199 (10.1) | 195 (9.9) | 0.208 |
Dyslipidemia | 3992 (67.4) | 1369 (69.3) | 1324 (67.1) | 1299 (65.8) | 0.058 |
Prior PCI | 627 (10.6) | 193 (9.8) | 225 (11.4) | 209 (10.6) | 0.252 |
Clinical Presentation | |||||
SBP on admission, mm Hg | 135.2 ± 21.9 | 134.9 ± 21.1 | 136.4 ± 21.8 | 134.3 ± 22.9 | 0.004 |
Heart rate on admission, bpm | 75.0 ± 14.0 | 74.0 ± 12.8 | 74.1 ± 13.8 | 76.7 ± 15.2 | <0.001 |
GRACE score | 129.4 ± 36.7 | 119.3 ± 34.3 | 128.2 ± 34.4 | 140.8 ± 38.1 | <0.001 |
Diagnosis on admission | |||||
STEMI | 2062 (34.8) | 574 (29.1) | 640 (32.4) | 848 (43.0) | <0.001 |
NSTEMI-ACS | 3861 (65.2) | 1401 (70.9) | 1334 (67.6) | 1126 (57.0) | |
Laboratory results on admission | |||||
D-dimer, ng/mL | 125 (73, 230) | 57 (39, 73) | 125 (104, 148) | 328 (230, 518) | <0.001 |
Fibrinogen, g/L | 3.28 ± 0.82 | 3.13 ± 0.72 | 3.27 ± 0.76 | 3.42 ± 0.95 | <0.001 |
Troponin-I, ng/mL | 0.41 (0.01, 11.78) | 0.9 (0.01, 7.14) | 0.21 (0.01, 6.81) | 1.43 (0.03, 22.85) | <0.001 |
Creatinine, umol/l | 72 (61, 85) | 70 (60, 82) | 72 (61, 83) | 75 (61, 91) | <0.001 |
Albumin, g/L | 39.5 ± 3.9 | 40.5 ± 3.6 | 39.7 ± 3.7 | 38.3 ± 3.9 | <0.001 |
Hemoglobin, g/L | 136.6 ± 16.8 | 141.1 ± 15.1 | 136.5 ± 15.9 | 132.3 ± 18.1 | <0.001 |
Leukocyte count (× 109/L) | 8.30 ± 2.99 | 8.09 ± 2.83 | 8.17 ± 2.84 | 8.63 ± 3.25 | <0.001 |
Platelet count (×109/L) | 206.6 ± 60.2 | 206.1 ± 57.1 | 207.7 ± 59.2 | 206.0 ± 64.1 | 0.476 |
BNP, ng/L | 123 (41, 342) | 108 (95, 131) | 114 (42, 303) | 214 (77, 547) | <0.001 |
Percutaneous coronary intervention details | |||||
Left main disease | 527 (8.9) | 141 (7.1) | 179 (9.1) | 207 (10.5) | 0.001 |
Three-vessel disease | 1496 (25.3) | 413 (20.9) | 513 (26.0) | 570 (28.9) | <0.001 |
Use of Intra-aortic Balloon Pump | 190 (3.2) | 36 (1.8) | 57 (2.9) | 97 (4.9) | <0.001 |
TIMI flow grade 0/1 on arrival | 4610 (77.8) | 1539 (77.9) | 1480 (75.0) | 1591 (80.6) | <0.001 |
TIMI flow grade 3 post PCI | 5899 (99.6) | 1973 (99.9) | 1968 (99.7) | 1958 (99.2) | 0.001 |
In-hospital Mortality | 53 (0.9) | 9 (0.5) | 6 (0.3) | 38 (1.9) | <0.001 |