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Table 1 Baseline Characteristics of the study population, median (IQR), or N (%), or means±SD

From: Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study

Variable

Overall (n = 5923)

Low D-dimer group (n = 1975)

Intermediate D-dimer group (n = 1974)

High D-dimer group(n = 1974)

p-value

Demographics

 Age, yrs

62.2 ± 11.3

58.4 ± 10.2

62.9 ± 10.5

65.2 ± 12.1

<0.001

 male

4117 (69.5)

1495 (75.7)

1343 (68.0)

1279 (64.8)

<0.001

Medical history

 History of Diabetes Mellitus

1875 (31.7)

595 (30.1)

630 (31.9)

650 (32.9)

0.159

 History of Hypertension

3517 (59.4)

1116 (56.5)

1228 (62.2)

1173 (59.4)

0.001

 History of MI

563 (9.5)

169 (8.6)

199 (10.1)

195 (9.9)

0.208

 Dyslipidemia

3992 (67.4)

1369 (69.3)

1324 (67.1)

1299 (65.8)

0.058

 Prior PCI

627 (10.6)

193 (9.8)

225 (11.4)

209 (10.6)

0.252

Clinical Presentation

 SBP on admission, mm Hg

135.2 ± 21.9

134.9 ± 21.1

136.4 ± 21.8

134.3 ± 22.9

0.004

 Heart rate on admission, bpm

75.0 ± 14.0

74.0 ± 12.8

74.1 ± 13.8

76.7 ± 15.2

<0.001

 GRACE score

129.4 ± 36.7

119.3 ± 34.3

128.2 ± 34.4

140.8 ± 38.1

<0.001

Diagnosis on admission

 STEMI

2062 (34.8)

574 (29.1)

640 (32.4)

848 (43.0)

<0.001

 NSTEMI-ACS

3861 (65.2)

1401 (70.9)

1334 (67.6)

1126 (57.0)

Laboratory results on admission

 D-dimer, ng/mL

125 (73, 230)

57 (39, 73)

125 (104, 148)

328 (230, 518)

<0.001

 Fibrinogen, g/L

3.28 ± 0.82

3.13 ± 0.72

3.27 ± 0.76

3.42 ± 0.95

<0.001

 Troponin-I, ng/mL

0.41 (0.01, 11.78)

0.9 (0.01, 7.14)

0.21 (0.01, 6.81)

1.43 (0.03, 22.85)

<0.001

 Creatinine, umol/l

72 (61, 85)

70 (60, 82)

72 (61, 83)

75 (61, 91)

<0.001

 Albumin, g/L

39.5 ± 3.9

40.5 ± 3.6

39.7 ± 3.7

38.3 ± 3.9

<0.001

 Hemoglobin, g/L

136.6 ± 16.8

141.1 ± 15.1

136.5 ± 15.9

132.3 ± 18.1

<0.001

 Leukocyte count (× 109/L)

8.30 ± 2.99

8.09 ± 2.83

8.17 ± 2.84

8.63 ± 3.25

<0.001

 Platelet count (×109/L)

206.6 ± 60.2

206.1 ± 57.1

207.7 ± 59.2

206.0 ± 64.1

0.476

 BNP, ng/L

123 (41, 342)

108 (95, 131)

114 (42, 303)

214 (77, 547)

<0.001

Percutaneous coronary intervention details

 Left main disease

527 (8.9)

141 (7.1)

179 (9.1)

207 (10.5)

0.001

 Three-vessel disease

1496 (25.3)

413 (20.9)

513 (26.0)

570 (28.9)

<0.001

 Use of Intra-aortic Balloon Pump

190 (3.2)

36 (1.8)

57 (2.9)

97 (4.9)

<0.001

 TIMI flow grade 0/1 on arrival

4610 (77.8)

1539 (77.9)

1480 (75.0)

1591 (80.6)

<0.001

 TIMI flow grade 3 post PCI

5899 (99.6)

1973 (99.9)

1968 (99.7)

1958 (99.2)

0.001

 In-hospital Mortality

53 (0.9)

9 (0.5)

6 (0.3)

38 (1.9)

<0.001

  1. MI Myocardial infarction, PCI Percutaneous coronary intervention, SBP Systolic blood pressure, bpm Beats per minute, STEMI ST-segment elevation myocardial infarction, NSTEMI-ACS Non-ST-segment elevation myocardial infarction of acute coronary syndrome, BNP Brain natriuretic peptide