Risk factor | HR (95% CI) | |||||
---|---|---|---|---|---|---|
Univariable model | p value | Multivariable model* | p value | Multivariable model** | p value | |
Age (continuous) | 1.03 (1.01–1.05) | 0.001 | 1.04 (1.02–1.06) | 0.001 | 1.04 (1.02–1.06) | < 0.001 |
Age (categorical), years | ||||||
< 34 | Ref | |||||
35–44 | 0.66 (0.06–7.28) | 0.733 | ||||
45–54 | 1.29 (0.15–10.73) | 0.815 | ||||
55–64 | 1.34 (0.18–9.88) | 0.774 | ||||
≥ 65 | 2.24 (0.31–16.03) | 0.428 | ||||
Sex | ||||||
Male | Ref | Ref | Ref | |||
Female | 1.40 (0.92–2.14) | 0.115 | 1.96 (1.22–3.15) | 0.005 | 1.55 (1.01–2.37) | 0.043 |
Smoking | ||||||
No | Ref | Ref | ||||
Yes | 1.01 (0.67–1.53) | 0.958 | 1.26 (0.80–1.99) | 0.319 | ||
SBP | 1.01 (1.00–1.02) | 0.156 | 1.01 (1.00–1.02) | 0.166 | ||
DBP | 1.00 (0.98–1.01) | 0.689 | 0.99 (0.97–1.02) | 0.581 | ||
Hypertension grade | ||||||
Normal | Ref | |||||
Grade 1 | 0.86 (0.56–1.33) | 0.506 | ||||
Grade 2 | 2.47 (1.37–4.43) | 0.003 | ||||
Grade 3 | 1.49 (0.54–4.12) | 0.439 | ||||
Diabetes mellitus | ||||||
No | Ref | Ref | Ref | |||
Yes | 1.45 (0.97–2.18) | 0.072 | 2.04 (1.29–3.22) | 0.002 | 1.79 (1.17–2.73) | 0.007 |
LDL (continuous) | 0.96 (0.80–1.15) | 0.634 | 0.99 (0.82–1.19) | 0.927 | ||
LDL (categorical), mmol/L | ||||||
< 2.6 | Ref | |||||
≥ 2.6 | 0.94 (0.65–1.38) | 0.767 | ||||
BMI (continuous) | 0.98 (0.94–1.02) | 0.228 | 0.96 (0.92–1.00) | 0.065 | ||
BMI (categorical), kg/m2 | ||||||
≤ 24.9 | Ref | |||||
25–29.9 | 0.98 (0.63–1.506) | 0.910 | ||||
30–34.9 | 0.55 (0.31–0.98) | 0.044 | ||||
35+ | 1.43 (0.73–2.81) | 0.293 | ||||
Anti-platelet medication | ||||||
No | Ref | Ref | ||||
Yes | 0.85 (0.58–1.23) | 0.380 | 0.73 (0.50–1.08) | 0.114 |