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Table 1 Systemic hemodynamics

From: Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs

Hemodynamic Parameter

Temp.

Timepoint

RES

CME

LPS

SEVO

Dob

HR

HT

Baseline

    

98 ± 12.8

(1 min− 1)

 

After Intervention

    

122 ± 10.1c

 

NT

Baseline

89 ± 10.6

89 ± 11.8

97 ± 10

90 ± 14.7

89 ± 13.2

  

After Intervention

84 ± 13.2

101 ± 18.5*

128 ± 17.4*

79 ± 9.6*

114 ± 10.2a, c

 

MH

Baseline

86 ± 16.7

88 ± 10.8

98 ± 11.3

70 ± 10.1

65 ± 8a, b

  

After Intervention

59 ± 10.7*†

67 ± 11.4*†

79 ± 11.6*†

60 ± 5.9*

83 ± 11.2a, b, c

MAP

HT

Baseline

    

74 ± 8.4

(mmHg)

 

After Intervention

    

77 ± 12.3

 

NT

Baseline

92 ± 11.7

104 ± 17.3

86 ± 4.6

75 ± 7.1

68 ± 8

  

After Intervention

64 ± 8.2*

54 ± 13*

53 ± 10.6*

44 ± 4.9*

71 ± 11.8

 

MH

Baseline

90 ± 8.7

107 ± 10.3

85 ± 5.9

67 ± 7.7

65 ± 7.7a

  

After Intervention

73 ± 15.4*

69 ± 6.7*†

58 ± 2.9*

42 ± 3.3*

69 ± 6.5a

CO

HT

Baseline

    

6.7 ± 0.9

(L min−1)

 

After Intervention

    

8.4 ± 1c

 

NT

Baseline

5.7 ± 1.2

6.2 ± 0.9

6.8 ± 0.5

6.7 ± 0.6

6.1 ± 1

  

After Intervention

4.8 ± 1.1

3.5 ± 0.7*

6.6 ± 1.3

5.0 ± 0,8*

7.8 ± 1.1c

 

MH

Baseline

5.4 ± 1.3

6.5 ± 0.9

6.2 ± 0.8

4.9 ± 0.6

4.4 ± 0.6 a, b

  

After Intervention

3.5 ± 0.7*†

3.2 ± 0.5*

4.5 ± 1.22*†

4.4 ± 0.6

6.0 ± 0.85a, b, c

SVR

HT

Baseline

    

842 ± 152

(dyne.sec cm−5)

 

After Intervention

    

717 ± 170c

 

NT

Baseline

1238 ± 401

1292 ± 345

931 ± 76

848 ± 97

856 ± 171

  

After Intervention

915 ± 219

1089 ± 256

531 ± 83*

620 ± 117*

703 ± 128c

 

MH

Baseline

1252 ± 310

1260 ± 153

1018 ± 139

1030 ± 137

1154 ± 202a, b

  

After Intervention

1470 ± 384†

1618 ± 252*†

884 ± 206†

675 ± 183*

880 ± 88a, b, c

CPO

HT

Baseline

    

1.10 ± 0.2

(W)

 

After Intervention

    

1.40 ± 0.3c

 

NT

Baseline

1.14 ± 0.2

1.43 ± 0.3

1.29 ± 0.1

1.12 ± 0.2

0.90 ± 0.2

  

After Intervention

0.69 ± 0.24*

0.42 ± 0.2*

0.80 ± 0.3*

0.48 ± 0.1*

1.20 ± 0.3a, c

 

MH

Baseline

1.09 ± 0.3

1.55 ± 0.3

1.17 ± 0.2

0.72 ± 0.1

0.60 ± 0.1a, b

  

After Intervention

0.58 ± 0.2*

0.49 ± 0.1*

0.58 ± 0.2*

0.40 ± 0.0*

0.90 ± 0.2a, b, c

  1. All values are presented as mean ± standard deviation (SD). Temp. Temperature, HT Hyperthermia, NT Normothermia, MH Mild hypothermia, RES Resuscitation after ventricular fibrillation, CME Coronary microembolisation, LPS Endotoxemia by Lipopolysaccharide (LPS)-infusion, SEVO Sevoflurane-induced myocardial depression, Dob Temperature modulation from hyperthermia to mild hypothermia vs. dobutamine (intervention) at each temperature step, HR Heart rate, MAP Mean aortic pressure, CO Cardiac Output, SVR Systemic vascular resistance, CPO Cardiac Power Output
  2. *p < 0.05 vs baseline; †p < 0.05 vs NT; ap < 0.05 vs hyperthermia; bp < 0.05 vs normothermia; cp < 0.05 vs baseline at each temperature step