Hemodynamic Parameter
|
Temp.
|
Timepoint
|
RES
|
CME
|
LPS
|
SEVO
|
Dob
|
---|
HR
|
HT
|
Baseline
| | | | |
98 ± 12.8
|
(1 min− 1)
| |
After Intervention
| | | | |
122 ± 10.1c
|
|
NT
|
Baseline
|
89 ± 10.6
|
89 ± 11.8
|
97 ± 10
|
90 ± 14.7
|
89 ± 13.2
|
| |
After Intervention
|
84 ± 13.2
|
101 ± 18.5*
|
128 ± 17.4*
|
79 ± 9.6*
|
114 ± 10.2a, c
|
|
MH
|
Baseline
|
86 ± 16.7
|
88 ± 10.8
|
98 ± 11.3
|
70 ± 10.1
|
65 ± 8a, b
|
| |
After Intervention
|
59 ± 10.7*†
|
67 ± 11.4*†
|
79 ± 11.6*†
|
60 ± 5.9*
|
83 ± 11.2a, b, c
|
MAP
|
HT
|
Baseline
| | | | |
74 ± 8.4
|
(mmHg)
| |
After Intervention
| | | | |
77 ± 12.3
|
|
NT
|
Baseline
|
92 ± 11.7
|
104 ± 17.3
|
86 ± 4.6
|
75 ± 7.1
|
68 ± 8
|
| |
After Intervention
|
64 ± 8.2*
|
54 ± 13*
|
53 ± 10.6*
|
44 ± 4.9*
|
71 ± 11.8
|
|
MH
|
Baseline
|
90 ± 8.7
|
107 ± 10.3
|
85 ± 5.9
|
67 ± 7.7
|
65 ± 7.7a
|
| |
After Intervention
|
73 ± 15.4*
|
69 ± 6.7*†
|
58 ± 2.9*
|
42 ± 3.3*
|
69 ± 6.5a
|
CO
|
HT
|
Baseline
| | | | |
6.7 ± 0.9
|
(L min−1)
| |
After Intervention
| | | | |
8.4 ± 1c
|
|
NT
|
Baseline
|
5.7 ± 1.2
|
6.2 ± 0.9
|
6.8 ± 0.5
|
6.7 ± 0.6
|
6.1 ± 1
|
| |
After Intervention
|
4.8 ± 1.1
|
3.5 ± 0.7*
|
6.6 ± 1.3
|
5.0 ± 0,8*
|
7.8 ± 1.1c
|
|
MH
|
Baseline
|
5.4 ± 1.3
|
6.5 ± 0.9
|
6.2 ± 0.8
|
4.9 ± 0.6
|
4.4 ± 0.6 a, b
|
| |
After Intervention
|
3.5 ± 0.7*†
|
3.2 ± 0.5*
|
4.5 ± 1.22*†
|
4.4 ± 0.6
|
6.0 ± 0.85a, b, c
|
SVR
|
HT
|
Baseline
| | | | |
842 ± 152
|
(dyne.sec cm−5)
| |
After Intervention
| | | | |
717 ± 170c
|
|
NT
|
Baseline
|
1238 ± 401
|
1292 ± 345
|
931 ± 76
|
848 ± 97
|
856 ± 171
|
| |
After Intervention
|
915 ± 219
|
1089 ± 256
|
531 ± 83*
|
620 ± 117*
|
703 ± 128c
|
|
MH
|
Baseline
|
1252 ± 310
|
1260 ± 153
|
1018 ± 139
|
1030 ± 137
|
1154 ± 202a, b
|
| |
After Intervention
|
1470 ± 384†
|
1618 ± 252*†
|
884 ± 206†
|
675 ± 183*
|
880 ± 88a, b, c
|
CPO
|
HT
|
Baseline
| | | | |
1.10 ± 0.2
|
(W)
| |
After Intervention
| | | | |
1.40 ± 0.3c
|
|
NT
|
Baseline
|
1.14 ± 0.2
|
1.43 ± 0.3
|
1.29 ± 0.1
|
1.12 ± 0.2
|
0.90 ± 0.2
|
| |
After Intervention
|
0.69 ± 0.24*
|
0.42 ± 0.2*
|
0.80 ± 0.3*
|
0.48 ± 0.1*
|
1.20 ± 0.3a, c
|
|
MH
|
Baseline
|
1.09 ± 0.3
|
1.55 ± 0.3
|
1.17 ± 0.2
|
0.72 ± 0.1
|
0.60 ± 0.1a, b
|
| |
After Intervention
|
0.58 ± 0.2*
|
0.49 ± 0.1*
|
0.58 ± 0.2*
|
0.40 ± 0.0*
|
0.90 ± 0.2a, b, c
|
- All values are presented as mean ± standard deviation (SD). Temp. Temperature, HT Hyperthermia, NT Normothermia, MH Mild hypothermia, RES Resuscitation after ventricular fibrillation, CME Coronary microembolisation, LPS Endotoxemia by Lipopolysaccharide (LPS)-infusion, SEVO Sevoflurane-induced myocardial depression, Dob Temperature modulation from hyperthermia to mild hypothermia vs. dobutamine (intervention) at each temperature step, HR Heart rate, MAP Mean aortic pressure, CO Cardiac Output, SVR Systemic vascular resistance, CPO Cardiac Power Output
- *p < 0.05 vs baseline; †p < 0.05 vs NT; ap < 0.05 vs hyperthermia; bp < 0.05 vs normothermia; cp < 0.05 vs baseline at each temperature step