Going beyond classic echo in aortic stenosis: left atrial mechanics, a new marker of severity

Table 5 Cox regression analysis results

Outcomes	Predictors	HR (95%CI)	P value
Heart failure	LA-SRs	0.17 (0.1-0.8)	0.022
	GLS	1.11 (1.0-1.3)	0.045
	BNP	1.0 (0.9-1.01)	0.810
	E/e’ ratio	1.0 (0.9-1.1)	0.710
	TAPSE	0.96 (0.84-1.1)	0.522
	RV/RA gradient	1.0 (0.9-1.1)	0.667
Aortic valve replacement	Mean gradient	1.40 (1.1-1.6)	< 0.001
	AVA	0.04 (0.01-0.14)	< 0.001
	LA ɛsys	0.95 (0.91-0.99)	0.027
	LA ɛe	0.91 (0.85-0.98)	0.026
Death	BNP	1.2 (1.0-1.3)	0.002
	LA ɛe	0.84 (0.74-0.96)	0.010
	GLS	1.22 (1.08-1.41)	0.003
Combined outcome	LV-GLS (%)	1.16 (1.08-1.23)	< 0.001
	LA ɛsys (%)	0.9 (0.92-0.93)	< 0.001
	Global strain	0.95 (0.93-0.98)	0.035
	E/e’ ratio	1.01 (0.97-1.04)	0.667
	TAPSE (mm)	0.97 (0.01-1.03)	0.414
	RV/RA gradient	1.01 (0.98-1.04)	0.285

LA ɛsys left atrial systolic strain (reservoir function), LA ɛe left atrial early diastolic strain (conduit function), LA ɛa left atrial late diastolic strain (contractile function), LA SRs left atrial systolic strain rate (reservoir function), LA SRe left atrial early diastolic strain rate (conduit function), LA SRa left atrial late diastolic strain (contractile function), LV-GLS left ventricular global longitudinal strain, RV/RA gradient right ventricle/right atrium gradient, TAPSE tricuspid annular plane systolic excursion

ISSN: 1471-2261