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Fig. 2 | BMC Cardiovascular Disorders

Fig. 2

From: Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats

Fig. 2

Effects of berberine on isoprenaline-induced cardiac dysfunction. (a) Representative M-mode images of the rat hearts. (b) Berberine (BBR) pretreatment attenuated an isoprenaline (ISO)-induced increase in the interventricular septum thickness at diastole and left ventricular end-diastolic posterior wall thickness. (n = 5–7 rats per experimental group) (c) Normalization of hemodynamic parameters with BBR pretreatment. (n = 5–6 rats per experimental group) *P < 0.05 as compared with the control group. #p < 0.05 vs. the ISO group. Abbreviations: CON, control group; ISO, isoprenaline; BBR, berberine; CTGF, connective tissue growth factor; TGF-β1, transforming growth factor β1; LVPWd, left ventricular end-diastolic posterior wall thickness; IVSd, interventricular septum thickness at diastole; EDP, end-diastolic pressure; ESV, end-systolic volume; Tau_w, time constant of isovolumic pressure decay; SV, stroke volume; EF, ejection fraction; CO, cardiac output

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