Low –dose chest CT and search for CTCs | No incidental lung nodule or nodule(s) <50mm3 | Incidental lung nodule(s) with volume between 50 and 500mm3 | Nodule(s) >500mm3 |
---|---|---|---|
No CTC | Next screening round at one year | Measure of volume doubling time at low-dose chest CT 3 months later | Diagnostic and pretherapeutic evaluation |
Presence of CTC | Contrast enhanced whole-body scanner and PET/CT examination of the head and neck cytological examination of the urine | Diagnostic and pretherapeutic evaluation | Diagnostic and pretherapeutic evaluation |