Table 1 Included studies and baseline characteristics of the patients
Study code a | Publication, first author, study acronym | Year | Study design | Indication | Number of patients | Male gender (%) | Mean age (years) | Treatment duration (months) | Follow-up (months) |
|---|---|---|---|---|---|---|---|---|---|
01 | Finkelstein Y. et al. [19] | 2002 | Multicenter, randomized, double blind | PPS prevention | 111 | 73 | 64.0 | 1 | 3 |
02 | Imazio M. et al., CORE [20] | 2005 | Single center, randomized, open label | PER recurrence | 84 | 35 | 53.8 | 6 | 20 |
03 | Imazio M. et al., COPE [21] | 2005 | Multicenter, randomized, open label | PER first episode | 120 | 45 | 56.9 | 3 | 24 |
04 | Imazio M. et al., COPPS [22] | 2010 | Multicenter, randomized, double blind | PPS prevention | 360 | 66 | 65.7 | 1 | 19 |
05 | Imazio M. et al., CORP [23] | 2011 | Multicenter, randomized, double blind | PER recurrence | 120 | 52.5 | 47.6 | 6 | 18 |
06 | Imazio M. et al., ICAP [24] | 2013 | Multicenter, randomized, double blind | PER first episode | 240 | 60 | 52.1 | 3 | 22 |
07 | Imazio M. et al., COPPS-2 (11) | 2014 | Multicenter, randomized, double blind | PPS prevention | 360 | 69 | 67.5 | 1 | 3,1 |
08 | Imazio M. et al., CORP-2 (10) | 2014 | Multicenter, randomized, double blind | PER recurrence | 240 | 50 | 48.8 | 6 | 20 |
09 | Meurin P. et al., POPE-2 (21) | 2015 | Multicenter, randomized, double blind | PE post heart surgery | 197 | 86 | 64.5 | 0.5 | 6 |
10 | Izadi Amoli A. et al., [18] | 2015 | Single center, randomized, triple blind | PE post heart surgery | 149 | 60 | 57.4 | 0.5 | 1 |