TY - JOUR AU - Wagner, Jonathan AU - Knaier, Raphael AU - Infanger, Denis AU - Arbeev, Konstantin AU - Briel, Matthias AU - Dieterle, Thomas AU - Hanssen, Henner AU - Faude, Oliver AU - Roth, Ralf AU - Hinrichs, Timo AU - Schmidt-Trucksäss, Arno PY - 2019 DA - 2019/07/30 TI - Functional aging in health and heart failure: the COmPLETE Study JO - BMC Cardiovascular Disorders SP - 180 VL - 19 IS - 1 AB - Cardiovascular (CV) diseases including heart failure are the leading causes of morbidity, with age being the primary risk factor. The combination of age-related organic functional impairment and reduced physical fitness can drastically impact an individual’s healthspan. One’s lifespan can potentially be prolonged by the preservation or improvement of physical fitness. However, it remains unclear as to which biomarkers are most suitable for distinguishing between healthy aging and the impaired organ function associated with heart failure. Therefore, a comprehensive assessment of the components of physical fitness and CV function will be performed to identify the most important factors contributing to aging in relation to both health and disease. SN - 1471-2261 UR - https://doi.org/10.1186/s12872-019-1164-6 DO - 10.1186/s12872-019-1164-6 ID - Wagner2019 ER -