Fig. 1

Talin-1 is downregulated in the fibrous cap of unstable carotid plaque. a Western blot for Talin-1 expression in human carotid plaque (n = 3 per group). Talin-1 was significantly downregulated in unstable carotid plaque (P < 0.05). b qRT-PCR for Talin-1 expression in human carotid plaque (n = 10 per group). Talin-1 was significantly downregulated in unstable carotid plaque (P < 0.05). c Immunofluorescent on the same sections (n = 3) of carotid plaque with Talin-1 staining (n = 10 per group). Quantitative analysis of the results of immunofluorescent revealed that Talin-1 is distributed in the fibrous cap of carotid plaque and its content was significantly downregulated in unstable carotid plaque (P < 0.05). Data are represented as mean ± SD. n = 6 randomly chosen fields in each group