C1q/TNF-related protein 3 (CTRP3) and 9 (CTRP9) concentrations are decreased in patients with heart failure and are associated with increased morbidity and mortality

Table 1 Clinical and biochemical characteristics of control and HFrEF groups

Variables	Control (n = 176)	HFrEF (n = 168)	P
Age (years)	55.11 ± 13.44	57.25 ± 14.92	0.418
Sex, male (%)	116 (65.9%)	122(72.6%)	0.199
BMI (Kg/m²)	21.72 ± 1.78	23.45 ± 3.80	< 0.001
Diabetes mellitus (%)	0(0%)^a	40 (23.8%)	< 0.001
Hypertension (%)	0(0%)^a	66 (39.3%)	< 0.001
Myocardial infarction (%)	0(0%)^a	52 (31.0%)	< 0.001
Systolic pressure (mmHg)	108.86 ± 15.70	119.04 ± 20.71	0.071
Diastolic pressure (mmHg)	71.41 ± 10.90	75.96 ± 12.80	0.577
Fasting glucose (mmol/L)	4.72 ± 0.35	5.00 ± 1.75	0.004
HDL-cholesterol (mmol/L)	1.31 ± 0.19	0.93 ± 0.28	< 0.001
LDL-cholesterol (mmol/L)	1.67 ± 0.34	2.33 ± 0.88	< 0.001
Total Cholesterol (mmol/L)	4.16 ± 0.51	3.71 ± 0.98	0.001
Triglyceride (mmol/L)	0.95 ± 0.24	1.39 ± 0.86	< 0.001
Serum creatinine (umol/L)	91.11 ± 6.58	113.79 ± 32.89	< 0.001
Cystatin c (mg/L)	1.05 ± 0.23	1.38 ± 0.42	< 0.001
NT-proBNP (ng/L)	3.81 ± 2.55	9878.69 ± 9236.14	< 0.001
LVEF (%)	59.25 ± 2.35	28.67 ± 6.18	< 0.001
CTRP3 (ng/mL)	236.40 ± 62.86	173.30 ± 49.81	< 0.001
CTRP9 (ng/mL)	180.70 ± 51.05	124.60 ± 37.58	< 0.001

Data are expressed as mean ± SD or frequency (%)
P-values were calculated by an independent-samples t-test or chi-square test
BMI Body mass index, HDL High-density lipoprotein, LDL Low-density lipoprotein, NT-proBNP N-terminal pro-brain natriuretic peptide, LVEF Left ventricular ejection fraction, CTRP3 C1q/TNF-related protein 3, CTRP9 C1q/TNF-related protein 9
^aThese data were acquired by inquiry of medical history

ISSN: 1471-2261