Effectiveness and safety of direct oral anticoagulants compared to warfarin in treatment naïve non-valvular atrial fibrillation patients in the US Department of defense population

Table 2 Dose Sensitivity Analysis for Propensity Score Matched Patients

	Dabigatran vs Warfarin		P value*	Rivaroxaban vs Warfarin		P value*	Apixaban vs Warfarin		P value*
Stroke/SE
Reduced Dose	N = 566 vs N = 566	0.72 (0.25, 2.04)	0.857	N = 2561 vs N = 2561	0.77 (0.49, 1.20)	0.694	N = 1893 vs N = 1893	0.72 (0.38, 1.39)	0.315
Standard Dose	N = 3125 vs N = 3125	0.64 (0.39, 1.07)	0.857	N = 5665 vs N = 5665	0.86 (0.61, 1.22)	0.694	N = 5714 vs N = 5714	0.49 (0.32, 0.73)	0.315
Major bleeding
Reduced Dose	N = 566 vs N = 566	1.30 (0.70, 2.41)	0.369	N = 2561 vs N = 2561	0.84 (0.63, 1.12)	0.054	N = 1893 vs N = 1893	0.66 (0.46, 0.95)	0.803
Standard Dose	N = 3125 vs N = 3125	0.94 (0.68, 1.31)	0.369	N = 5665 vs N = 5665	1.19 (0.97, 1.47)	0.054	N = 5714 vs N = 5714	0.62 (0.48, 0.81)	0.803

ISSN: 1471-2261