Table 1 Baseline characteristics of heart failure patients previously on furosemide (N = 232)
Characteristic | All Patients (N = 232) n (%) | Torsemide Users (N = 45) n (%) | Optimized Furosemide Users (N = 187), n (%) | P-value |
|---|---|---|---|---|
Male Gender | 126 (54.3) | 24 (53.3) | 102 (54.5) | 0.88 |
Age* | 67 ± 11.7 | 65 ± 10.7 | 67 ± 11.9 | 0.23 |
Weight* | 83 ± 23.9 | 88 ± 24.3 | 82 ± 23.7 | 0.15 |
Heart Failure | 0.23 | |||
HFpEF | 100 (43.1) | 23 (51.1) | 77 (41.2) | |
HFrEF | 132 (56.9) | 22 (48.9) | 110 (58.8) | |
Ejection Fraction | 0.751§ | |||
< 20% | 8 (3.4) | 2 (4.4) | 6 (3.2) | |
20–25% | 38 (16.4) | 10 (22.2) | 28 (15.0) | |
25–30% | 32 (13.8) | 4 (8.9) | 28 (15.0) | |
30–35% | 32 (13.8) | 3 (6.7) | 29 (15.5) | |
35–40% | 22 (9.5) | 3 (6.7) | 19 (10.2) | |
40–45% | 25 (10.8) | 7 (15.6) | 18 (9.6) | |
45–50% | 30 (12.9) | 5 (11.1) | 25 (13.3) | |
> 50% | 45 (19.4) | 11 (24.4) | 34 (18.2) | |
Systolic Blood Pressure* | 119 ± 18.2 | 120 ± 17.6 | 119 ± 18.3 | 0.92 |
Diastolic Blood Pressure* | 67 ± 9.1 | 68 ± 9.5 | 67 ± 9.0 | 0.41 |
Heart Rate* | 74 ± 12.8 | 74 ± 12.6 | 74 ± 12.9 | 0.87 |
Serum Potassium* | 4.2 ± 0.46 | 4.15 ± 0.4 | 4.19 ± 0.47 | 0.55 |
Serum Creatinine* | 137 ± 82.8 | 144 ± 64.3 | 135 ± 86.7 | 0.51 |
Creatinine Clearance* | 61 ± 31.9 | 60 ± 27.9 | 61 ± 32.8 | 0.75 |
Serum Sodium* | 137 ± 4.4 | 137 ± 4.8 | 137 ± 4.3 | 0.82 |
Baseline Furosemide (mg)* | 66 ± 39 | 101 ± 47 | 57 ± 31 | < 0.001 |
IV Furosemide | 222 (95.7) | 40 (88.9) | 182 (97.3) | 0.026‡ |
Concurrent Medical Conditions | ||||
Atrial Fibrillation | 70 (30.2) | 17 (37.8) | 53 (28.3) | 0.22 |
Coronary Artery Disease | 158 (68.1) | 24 (53.3) | 134 (71.7) | 0.018 |
Hypertension | 199 (85.8) | 39 (86.7) | 160 (85.6) | 0.85 |
Dyslipidemia | 57 (24.6) | 9 (20.0) | 48 (25.7) | 0.43 |
Diabetes Mellitus | 185 (79.7) | 34 (75.6) | 151 (80.7) | 0.44 |
Chronic Kidney Disease | 99 (42.7) | 22 (48.9) | 77 (41.2) | 0.35 |
Mitral Regurgitation | 46 (19.8) | 12 (26.7) | 34 (18.2) | 0.2 |
Mitral Stenosis | 4 (1.7) | 0 (0.0) | 4 (2.1) | 0.1‡ |
Aortic Regurgitation | 4 (1.7) | 1 (2.2) | 3 (1.6) | 0.58‡ |
Aortic Stenosis | 14 (6) | 4 (8.9) | 10 (5.3) | 0.48‡ |
Tricuspid Regurgitation | 29 (12.5) | 8 (17.8) | 21 (11.2) | 0.23 |
CABG | 39 (16.8) | 6 (13.3) | 33 (17.6) | 0.49 |
PCI | 82 (35.3) | 12 (26.7) | 70 (37.4) | 0.18 |
ICD | 25 (10.8) | 7 (15.6) | 18 (9.6) | 0.28‡ |
CRTD | 14 (6.0) | 6 (13.3) | 8 (4.3) | 0.03‡ |
Pacemaker | 18 (7.8) | 5 (11.1) | 13 (7.0) | 0.36‡ |