CD36 gene polymorphism rs1761667 (G > A) is associated with hypertension and coronary artery disease in an Iranian population

Table 2 Genotype and allele frequencies of CD36 rs1761667 in the four study groups

SNP		(1) H-Tens (N = 52)	(2) CAD + H-Tens (N = 57)	(3) CAD (N = 65)	(4) Ctrl (N = 64)	P-value
SNP		(1) H-Tens (N = 52)	(2) CAD + H-Tens (N = 57)	(3) CAD (N = 65)	(4) Ctrl (N = 64)	1 vs. 2	1 vs. 3	1 vs. 4	2 vs. 3	2 vs. 4	3 vs. 4	1&2&3&4 ^€
rs1761667
GG		6 (0.12)	17 (0.30)	12 (0.18)	26 (0.4)	0.029	0.563	0.001	0.103	0.034	0.016	0.003
GA		40 (0.77)	38 (0.67)	45 (0.7)	30 (0.46)
AA		6 (0.12)	2 (0.03)	8 (0.12)	9 (0.14)
Allele G		52 (0.5)	72 (0.63)	69 (0.53)	82 (0.63)	0.050	0.640	0.045	0.112	0.990	0.102	0.086
Allele A		52(0.5)	42 (0.37)	61 (0.47)	48 (0.37)	0.050	0.640	0.045	0.112	0.990	0.102	0.086
HWE	P-value	0.0001	0.001	0.001	0.941
HWE	X²	15.076	10.664	9.880	0.005

(1) H-Tens Hypertension, (2) CAD + H-Tens Coronary Artery Disease and Hypertension, (3) CAD Coronary Artery Disease, (4) Ctrl Control, HWE Hardy-Weinberg Equilibrium. Data are presented as number (%).The differences of CD36 rs 1,761,667 genotype and allele frequencies between study groups were analyzed using Chi-square/Fisher’s exact tests
^€significant difference between the four groups (p < 0.05)

ISSN: 1471-2261