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Table 3 Metabolic parameters of subjects with and without fractures before and after parathyroidectomy

From: Parathyroidectomy improves cardiovascular risk factors in normocalcemic and hypercalcemic primary hyperparathyroidism

 

Subjects without fractures

Subjects with fractures

p

Pre-parathyroidectomy

 Cardiovascular risk score

12.71 ± 10.88

17.85 ± 7.04

0.199

 Diastolic BP (mmHg)

81.93 ± 6.29

89.50 ± 3.50

0.001

 Systolic BP (mmHg)

137.37 ± 16.61

141.010 ± 11.23

0.551

 iPTH (pg/ml)

163.71 ± 71.17

194.01 ± 98.26

0.282

 Calcium (mg/dl)

10.62 ± 0.77

11.06 ± 0.71

0.136

 Phosphorus (mg/dl)

2.69 ± 0.44

2.42 ± 0.49

0.119

 ALP (IU/L)

98.76 ± 27.35

155.63 ± 88.58

< 0.001

 Glucose (mg/dl)

93.92 ± 12.57

95.13 ± 20.42

0.814

 İnsulin (μIU/ml)

13.90 ± 5.65

8.57 ± 3.49

0.012

 HOMA-IR

3.22 ± 1.33

2.09 ± 1.16

0.026

 Total cholesterol (mg/dl)

206.67 ± 39.21

213.45 ± 34.48

0.643

 LDL-C (mg/dl)

126.19 ± 32.69

127.75 ± 23.59

0.897

 HDL-C (mg/dl)

49.63 ± 11.04

49.38 ± 9.39

0.429

 TG (mg/dl)

155.95 ± 57.35

196.63 ± 101.29

0.092

Post-parathyroidectomy

 Cardiovascular risk score

6.72 ± 4.92

14.75 ± 9.47

0.010

 Diastolic BP (mmHg)

77.43 ± 7.33

85.00 ± 6.48

0.059

 Systolic BP (mmHg)

123.83 ± 14.04

121.51 ± 25.43

0.779

 iPTH (pg/ml)

61.46 ± 23.57

61.04 ± 23.59

0.971

 Calcium (mg/dl)

8.94 ± 0.35

9.06 ± 0.44

0.552

 Phosphorus (mg/dl)

3.26 ± 0.36

2.77 ± 0.69

0.034

 ALP (IU/L)

81.04 ± 20.18

121.56 ± 27.24

0.001

 Glucose (mg/dl)

85.40 ± 6.01

78.25 ± 7.88

0.038

 İnsulin (μIU/ml)

11.81 ± 3.44

6.53 ± 3.26

0.007

 HOMA-IR

2.55 ± 0.80

1.47 ± 0.70

0.015

 Total cholesterol (mg/dl)

194.49 ± 37.62

207.00 ± 37.97

0.537

 LDL-C (mg/dl)

119.70 ± 32.10

119.25 ± 19.01

0.978

 HDL-C (mg/dl)

49.30 ± 9.23

51.25 ± 11.17

0.757

 TG (mg/dl)

133.36 ± 54.56

153.03 ± 84.59

0.530

  1. Data are shown as mean ± standard deviation (means±SD)
  2. Abbreviations: BP blood pressure, iPTH intact parathyroid hormone, 25(OH) vitamin D 25-hydroxyvitamin D3, HDL-C high-density-lipoprotein cholesterol, LDL-C low-density-lipoprotein cholesterol, TG triglycerides, HOMA-IR homestasis model assessment-insulin resistance index, ALP alkaline phosphatase, PHPT primary hyperparathyroidism
  3. Bold represents the significant p-values