Association between plasma lipid levels during acute coronary syndrome and long-term malignancy risk. The ABC-4* study on heart disease

Berton, Giuseppe; Cordiano, Rocco; Cavuto, Fiorella; Bagato, Francesco; Mahmoud, Heba Talat; Pasquinucci, Mattia

doi:10.1186/s12872-019-1092-5

Table 3 Cox Regression and Competitive Risks Analysis for Neoplasia Onset and mortality after Acute Coronary Syndrome

From: Association between plasma lipid levels during acute coronary syndrome and long-term malignancy risk. The ABC-4* study on heart disease

Variable	Univariable analysis			Multivariable analysis
	Univariable analysis			(fully adjusted model)^a			(parsimonious model)
	Hazard ratio (95% CI)	Z value	p value	Hazard ratio (95% CI)	Z value	p value	Hazard ratio (95% CI)	Z value	p value
Cox regression survival analysis
Neoplasia onset (n = 99)
Above median TC	0.6(0.4–0.8)	−2.9	0.003	0.6(0.4–0.9)	− 2.3	0.02	0.6(0.4–0.9)^b	−2.6	0.01
Continuous TC		−3.6	< 0.0001		−3.0	0.003		−2.3^c	0.002
Above median LDL-C	0.6(0.4–0.9)	− 2.6	0.009	0.6(0.4–0.9)	−2.0	0.04	0.6(0.4–0.9)^b	−2.3	0.02
Continuous LDL-C		−3.2	0.001		−2.5	0.01		−2.8^c	0.006
Above median HDL-C	1.1(0.7–1.6)	0.5	0.63	1.0(0.7–1.5)	−0.1	0.94	1.0(0.7–1.5)^c	−0.1	0.89
Continuous HDL-C		0.03	0.74		−0.7	0.50		−0.3^c	0.80
Above median TG	0.8(0.5–1.1)	−1.4	0.15	0.8(0.5–1.2)	−1.1	0.26	0.8(0.6–1.2)^c	−0.9	0.35
Continuous TG		−3.0	0.003		− 2.1	0.03		−2.1^c	0.04
Neoplasia-related death (n = 75)
Above median TC	0.4(0.3–0.7)	−3.4	0.001	0.5(0.3–0.9)	−2.3	0.02	0.5(0.3–0.8)^b	−2.8	0.005
Continuous TC		−4.3	< 0.001		−3.3	0.001		−3.7^c	< 0.001
Above median LDL-C	0.4(0.3–0.7)	−3.2	0.001	0.5(0.3–0.9)	−2.4	0.02	0.5(0.3–0.8) ^b	−2.9	0.004
Continuous LDL-C		−4.3	< 0.001		−3.3	0.001		−3.6^c	< 0.001
Above median HDL-C	1.3(0.9–2.1)	1.3	0.20	1.1(0.7–1.8)	0.4	0.66	1.1(0.7–1.7)^c	0.4	0.67
Continuous HDL-C		0.9	0.37		−0.1	0.91		0.21^c	0.83
Above median TG	0.7(0.4–1.0)	−1.6	0.10	0.8(0.5–1.3)	−0.8	0.43	0.8(0.5–1.3)^c	−0.9	0.37
Continuous TG		−3.0	0.003		−1.7	0.09		−1.8^c	0.06
Competitive risks survival analysis
Neoplasia onset (n = 99)
Above median TC	0.6(0.4–0.9)	−2.6	0.01	0.6(0.4–0.9)	−2.4	0.02	0.6(0.4–0.9)^d	−2.5	0.01
Continuous TC		−2.5	0.01		−2.6	0.01		−2.7	0.008
Above median LDL-C	0.7(0.4–0.9)	−2.1	0.04	0.6(0.4–0.9)	−2.0	0.04	0.7(0.4–0.9)^d	−2.1	0.04
Continuous LDL-C		−2.3	0.02		−2.3	0.02		−2.4	0.02
Above median HDL-C	1.1(0.7–1.6)	0.2	0.82	1.0(0.7–1.5)	0.1	0.95	1.0(0.7–1.5)^d	0.2	0.84
Continuous HDL-C		0.4	0.69		−0.1	0.93		0.3	0.79
Above median TG	0.8(0.5–1.2)	−1.0	0.30	0.8(0.5–1.3)	−0.9	0.36	0.8(0.5–1.2)^d	−1.2	0.25
Continuous TG		−2.4	0.01		−2.4	0.02		−2.6	0.01
Neoplasia-related death (n = 75)
Above median TC	0.5(0.3–0.8)	−3.1	0.002	0.5(0.3–0.9)	−2.5	0.01	0.5(0.3–0.8)^d	−2.9	0.003
Continuous TC		−3.2	0.001		−2.8	0.006		−3.3^d	0.001
Above median LDL-C	0.5(0.3–0.8)	−2.8	0.005	0.6(0.3–0.9)	−2.3	0.02	0.5(0.3–0.8)^d	−2.7	0.007
Continuous LDL-C		−3.3	0.001		−2.7	0.007		−3.3^d	0.001
Above median HDL-C	1.3(0.8–2.0)	1.0	0.32	1.2(0.8–1.9)	0.8	0.44	1.3(0.8–2.0)^d	1.0	0.32
Continuous HDL-C		1.0	0.31		0.5	0.60		0.9^d	0.35
Above median TG	0.7(0.5–1.2)	−1.3	0.19	0.8(0.5–1.3)	−0.8	0.41	0.7(0.5–1.1)^d	−1.4	0.16
Continuous TG		−2.6	0.008		−2.1	0.04		−2.8^d	0.006

ACS Acute coronary syndrome, CI Confidence interval, HDL High-density lipoproteins, LDL Low-density lipoproteins
^aAdjusted for age, gender, BMI, smoking, diabetes mellitus, hypertension, in-hospital HF, Q-wave myocardial infarction, statin therapy, and hospital
^bAdjusted for age, smoking, and Q-wave myocardial infarction
^cAdjusted for age and smoking
^dAdjusted for smoking and in-hospital HF

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