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Table 8 All-cause mortality analysis with Bootstrapped DerSimonian-Laird random-effect model calculated by STATA

From: Comparing clinical outcomes of NOACs with warfarin on atrial fibrillation with Valvular heart diseases: a meta-analysis

STUDY

Overall

Subgroup: VHD

Subgroup: TAVI

Sensitivity Test

Harbord’s modified test

RR

95%CI

Weight(%)

RR

95%CI

Weight(%)

RR

95%CI

Weight(%)

RR

95%CI

p-Value

ARISTOTLE, 2015

1.004

0.839, 1.200

21.54

1.004

0.839, 1.200

25.42

 

0.792

0.494, 1.271

0.674

ENGAGE AF-TIMI 48, 2017

1.071

0.894, 1.282

21.52

1.071

0.894, 1.282

25.4

0.779

0.498, 1.221

RE-LY, 2016

0.456

0.373, 0.559

21.23

0.456

0.373, 0.559

25.05

1.018

0.910, 1.139

ROCKET AF, 2014

0.952

0.738, 1.228

20.46

0.952

0.738, 1.228

24.14

0.806

0.515, 1.26

Seeger, 2017

0.372

0.073, 1.883

4.18

 

0.372

0.073, 1.883

34.42

0.864

0.599, 1.247

Geis, 2018

1.218

0.554, 2.681

11.08

1.218

0.554, 2.681

65.58

0.797

0.543, 1.171

Overall

0.835

0.578, 1.205

100

0.827

0.556, 1.229

100

0.811

0.244, 2.692

100

0.835

0.584, 1.195

Heterogeneity Measures

Value

df

p-value

Value

df

p-value

Value

df

p-value

  

Cochran’s Q

48.87

5

0

46.38

3

0

1.65

1

0.2

Heterogeneity Measures

Value (95%CI)

Value (95%CI)

Value (95%CI)

I2 (%)

87.89

76.10, 93.86

93.48

86.52, 96.52

49.35

0.00, 100.00

H2

8.26

4.18, 16.30

15.35

7.42, 31.76

1.97

/

tau2 (BDL)

0.155

0.153

0.408