Table 7 Major bleeding Analysis with Bootstrapped DerSimonian-Laird random-effects model calculated by STATA
STUDY | Overall | Subgroup: VHD | Subgroup: TAVI | Sensitivity Test | Harbord’s modified test | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
RR | 95%CI | Weight(%) | RR | 95%CI | Weight(%) | RR | 95%CI | Weight(%) | RR | 95%CI | p-Value | |
ARISTOTLE, 2015 | 0.809 | 0.623, 1.049 | 19.42 | 0.809 | 0.623, 1.049 | 24.61 | 0.698 | 0.395, 1.234 | 0.585 | |||
ENGAGE AF-TIMI 48, 2017 | 0.568 | 0.432, 0.749 | 19.27 | 0.568 | 0.432, 0.749 | 24.43 | 0.756 | 0.437, 1.31 | ||||
RE-LY, 2016 | 0.39 | 0.319, 0.477 | 19.99 | 0.39 | 0.319, 0.477 | 25.27 | 0.831 | 0.592, 1.169 | ||||
ROCKET AF, 2014 | 1.124 | 0.965, 1.309 | 20.35 | 1.124 | 0.965, 1.309 | 25.69 | 0.621 | 0.422, 0.915 | ||||
Seeger, 2017 | 0.664 | 0.216, 2.039 | 8.78 | 0.664 | 0.216, 2.039 | 34.06 | 0.72 | 0.446, 1.164 | ||||
Geis, 2018 | 1.117 | 0.498, 2.503 | 12.19 | 1.117 | 0.498, 2.503 | 65.94 | 0.671 | 0.411, 1.093 | ||||
Overall | 0.714 | 0.461, 1.105 | 100 | 0.672 | 0.402, 1.122 | 100 | 0.935 | 0.486, 1.801 | 100 | 0.715 | 0.455, 1.122 | |
Heterogeneity Measures | Value | df | p-value | Value | df | p-value | Value | df | p-value | |||
Cochran’s Q | 71.36 | 5 | 0 | 74.19 | 3 | 0 | 0.055 | 1 | 0.459 | |||
Heterogeneity Measures | Value (95%CI) | Value (95%CI) | Value (95%CI) | |||||||||
I2 (%) | 91.12 | 83.43, 95.24 | 95.58 | 91.54, 97.69 | 0 | 0.00, 100.00 | ||||||
H2 | 11.26 | 6.03, 21.00 | 22.62 | 11.82, 43.30 | 1 | / | ||||||
tau2 (BDL) | 0.238 | 0.261 | 0 | |||||||||