Table 1 Baseline patient characteristics
SAVR + CABG | TAVR + OP/MIDCAB | TAVR + PCI | p-value (across groups) | |
|---|---|---|---|---|
(n = 464) | (n = 50) | (n = 112) | ||
mean ± SD or median (IQR) or n (%) | mean ± SD or median (IQR) or n (%) | mean ± SD or median (IQR) or n (%) | ||
Age (years) | 78.7 ± 3.1 | 82.1 ± 4.3 | 81.3 ± 5.7 | < 0.001 |
Female gender | 168 (36.2) | 19 (38.0) | 39 (34.8) | 0.923 |
BMI (kg/m2) | 26.2 ± 3.8 | 26.1 ± 4.7 | 26.0 ± 3.9 | 0.011 |
Clinical history | ||||
History of stroke/TIA | 46 (9.9) | 7 (14.0) | 16 (14.3) | 0.675 |
History of MI (< 90 days) | 138 (29.8) | 28 (56.0) | 79 (70.5) | 0.318 |
Previous cardiac surgery | 21 (4.5) | 1 (2.0) | 38 (33.9) | < 0.001 |
Diabetes mellitus | 180 (38.8) | 19 (38.0) | 33 (29.5) | 0.318 |
Hypertension | 454 (98.1) | 50 (100.0) | 109 (97.3) | 0.516 |
Pulmonary disease | 56 (12.1) | 9 (18.0) | 27 (24.1) | 0.020 |
Pulmonary hypertensiona | 128 (27.6) | 27 (54.0) | 62 (55.4) | < 0.001 |
Chronic kidney disease | ||||
Compensated | 115 (24.8) | 22 (44.0) | 49 (43.8) | < 0.001 |
Prior dialysis | 8 (1.7) | 3 (6.0) | 7 (6.3) | 0.014 |
Other valve disorders | ||||
Mitral | 235 (50.6) | 32 (64.0) | 86 (76.8) | < 0.001 |
Tricuspid | 17 (3.7) | 6 (12.0) | 12 (10.7) | < 0.001 |
EuroSCORE I (%) | 21.0 ± 17.5 | 36.4 ± 22.4 | 36.1 ± 18.9 | < 0.001 |
NYHA class | < 0.001 | |||
I/II | 206 (44.4) | 8 (16.0) | 10 (8.9) | |
III/IV | 258 (55.6) | 42 (84.0) | 102 (91.1) | |
Multi-vessel CAD | 359 (77.4) | 42 (84.0) | 83 (74.1) | 0.570 |
AV parameters | ||||
LVEF (%) | 55.7 ± 13.8 | 48.3 ± 14.4 | 51.3 ± 2.6 | < 0.001 |
EOA (cm2) | 0.8 ± 0.3 | 0.7 ± 0.2 | 0.7 ± 0.2 | < 0.001 |
Mean AV gradient (mmHg) | 40.7 ± 17.1 | 40.4 ± 14.0 | 42.5 ± 15.2 | 0.027 |
Peak AV gradient (mmHg) | 66.6 ± 25.7 | 67.9 ± 19.7 | 72.2 ± 23.3 | 0.150 |
Annulus size (cm2) | 22.9 ± 4.2 | 23.7 ± 2.2 | 22.9 ± 2.4 | 0.092 |