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Table 1 Summary of the principal studies on biomarkers and SCD

From: Predictors of cardiac arrhythmic events in non coronary artery disease patients

MARKER YEAR AUTHORS NUMBER OF PATIENTS POPULATION OUTCOMES RESULTS
BNP 2006 Verma A et al. 345 HF of mixed etiology ICD therapies Association between pre-implantation BNP levels and appropriate ICD shocks or anti-tachycardia pacing during time.
BNP & NT-proBNP 2014 Levine YC et al. 161 (NTproBNP) 403 (BNP) HF of mixed etiology VTs Levels of NT-proBNP and BNP were independently associated with risk for ventricular tachyarrhythmias
NT-proBNP 2008 Simon T et al. 30 Nonischemic cardiomyopathy (DCM) with LVEF <= 40% VTs or unexplained syncope NT-pro BNP levels were significantly correlated with occurrence of symptomatic VTs
C-reactive protein 2002 Albert CM et al. 97 cases of SCD among Physician’s Health Study population Healthy male physicians SCD CRP levels were significantly associated with the risk of SCD over 17 years of follow-up
C-reactive protein 2009 Korngold EC et al. 99 cases of SCD among Nurses’ Health Study population Healthy female nurses SCD No correlation between CRP and SCD
NEFA 1999 Jouven X et al 5250 Male employers of the city of Paris between 42 to 53 years of age SCD Circulating NEFA levels are an independent risk factor for SCD
Long chain n-3 fatty acids 2006 Lemaitre RN et al 214 cases of IHD among the Cardiovascular Health Study IHD (fatal myocardial infarction and coronary heart disease) Fatal IHD and SCD High levels of trans-18:1 fatty acids were associated with lower risk of SCD whereas high levels of trans-18:2 were associated with higher risk of SCD
Matrix metalloproteinase (MMPs), and tissue inhibitor of matrix metalloproteinase (TIMPs) 2010 EM Kanupakis et al. 70 Nonischemic cardiomyopathy (DCM) with LVEF <= 35% ICD therapies High levels of MMPs and TIMPs were linked to increase risk of ICD therapies
Osteopontin 2014 Francia P et al 75 HF of mixed etiology ICD therapies High levels of osteopontin are associated with appropriate ICD therapies.
Testosterone & estradiol 2017 D Akdis et al. 54 ARVC/D MACE High levels of testosterone and low levels of estradiol were linked to increase incidence of MACE
SCN5A mRNA in WBC 2014 Gao G et al. 43 HF of mixed etiology ICD therapies High levels of SCN5A mRNA in WBC were linked to increase risk of ICD therapies