Optimal INR level for warfarin therapy after mechanical mitral valve replacement

Table 3 The effect of repeated INR level and event outcome measures at time

	Mean INR	Standard error of mean	Mean difference (95% CI)	Effect Estimate (Beta)	Effect Standard Error	P-value
Thromboembolic	1.69	0.11	−0.86	−0.88	0.19	< 0.001
No Thromboembolic	2.55	0.01	(−1.24 to − 0.49)
Bleeding	5.05	0.53	2.53	2.52	0.154	< 0.001
No bleeding	2.53	0.01	(2.22 to 2.83)
Major	4.95	0.76	2.41	2.41	0.22	< 0.001
No major	2.54	0.01	(1.97 to 2.85)
Minor	5.16	0.79	2.63	2.61	0.22	0.002
No minor	2.54	0.01	(2.19 to 3.06)
Follow-up time point				0.004	0.003	0.121

The interaction effect between Thromboembolic, bleeding, minor bleeding and major bleeding event and time was non-significant (P-value > 0.05)

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