Table 1 Characteristics of included studies

COMPARE-ACUTE 2017 [7]

IRA plus non-IRA or their major side branches of at least 2.0 mm diameter show ≥50% stenosis by QCA or visual assessment

All-causemortality, nonfatal MI, any revascularization, cerebrovascular events

Non-IRAs with at least 50% stenosis and who had a FFR ≤0.80 were revascularized with Everolimus DES

Within 3 days

Hamza et al. 2016 [10]

IRA plus at least 80% stenosis in non-IRA

Composite of all- cause mortality, recurrent MI, ischemia driven revascularization with PCI or CABG

N-IRAs with at least 80% stenosis were revascularized.

Within 3 days

DANAMI-3- PRIMULTI 2015 [6]

IRA plus > 50% stenosis in one or more non-IRA

Composite of all- cause mortality, reinfarction, or ischemia driven revascularization of non–IRA

Non-IRAs which were ≥ 2 mm in diameter with at least 50% stenosis and FFR < 0.8 or those with visually

Estimated stenosis> 90% stenosis were treated with everolimus DES.

Within 2 days

PRAGUE − 132,015 [11]

at least 1 stenosis of non-IRA > 70% with diameter > 2.5 mm

All cause mortality, non- fatal MI and stroke.

NA

3–40 days

CvLPRIT 2015 [12]

IRA plus at least one non-IRA with at least one lesion> 70% single view/50% in two views

All-cause mortality, MI,HF, ischemia driven PCI OR CABG

Non-IRAs with at least > 70% stenosis in one view or > 50% stenosis in two views were revascularized with DES

Within 3 days

PRAMI 2013 [13]

IRA plus one or more non-IRA > 50% stenosis

Composite of death from cardiac cause, nonfatal MI, refractory angina.

Non-IRA stenoses > 50% were intervened

At the same procedure

Ghani et al. 2012 [14]

One or more stenoses of ≥50% (in at least one view visually or by QCA) in at least two major epicardial coronary arteries

Death, nonfatal reinfarction, unplanned revascularization

Vessel with significant stenosis vascularized if FFR < 0.75. For severe stenosis (> 90%) PCI performed without preceding FFR.

Within 3 weeks after STEMI

Politi et al. 2010 [15]

> 70% stenosis of at least two epicardial coronary arteries or their major branches

Death, reinfarction, rehospitalization for ACS and repeat coronary revascularization

Non-IRAs with PCI and angiographic residual stenosis of < 30% or TIMI flow grade of 3

56.8 ± 12.9 days

HELP AMI 2004 [16]

IRA plus at least 1–3 lesions in major non-IRA

Death, repeat MI, urgent revascularization

All suitable non-IRAs with heparin coated Bx velocity stents. Balloon dilatation alone was performed for lesions in vessels with diameter < 2.5 mm provided at least one non-IRA was treated with stents.

At the same procedure