Author, year | Samplesize, gender M/F | Mean age, years (SD) | Study population | NIC interventions | Control interventions | Outcome measures | Follow-up |
---|---|---|---|---|---|---|---|
Akagi, 2006 [21] | NIC: 10,6/4; 10,5/5 Control: 10,9/1 | 68 (9) 63 (15) 61(9) | Patients with AMI | IV drip infusion (4 mg/hr) before PCI for 48 h, 2 mg IC, and/not oral 15 mg/dayafter PCI | No NIC administered | LVEF | 3 months |
Chen, 2015 [22] | NIC: 26,18/8 Control: 26,19/7 | 57.6 (4.7) 59.8 (4.8) | Patients with AMI | IC2 mg before PCI | No NIC administered | LVEF; CK-MB; cTnI; MACEs | 1 months |
Fujiwara 2006 [23] | NIC: 31,25/6 Control: 31,25/6 | 62 (2) 62 (2) | Patients with AMI | 4 mg IV before PCI, IV drip infusion (8 mg/hr) for 24 h after PCI | No NIC administered | LVEF | 6 months |
Hwang, 2013 [25] | NIC: 41,20/21 Control: 40,25/15 | 66.2 (9) 65.3 (10) | Patients with angina | IC 4 mg before PCI | No NIC administered | CK-MB; cTnI | NR |
Ishii, 2005 [15] | NIC: 185,144/41 Control: 183,154/29 | 63 (9.4) 64 (10.1) | Patients with MI | 12 mg IV over 20–30 min before reperfusion with PCI | Placebo | MACEs | 5 years |
Isono, 2008 [16] | NIC: 23,19/4 Control: 26,21/5 | 66.3 (7.9) 66.5 (9.4) | Patients with CHD | 4 mg IV before PCI, IV drip infusion (6 mg/hr) for 24 h,oral15 mg/day3–6 months after PCI | No NIC administered | LVEF; CK-MB; cTnI | 3 months |
Ito, 1999 [17] | NIC: 40,32/8 Control: 41,32/9 | 60 (10) 60 (10) | Patients with first anterior AMI | 4 mg IV before PCI, IV drip infusion (6 mg/hr) for 24 h,oral15 mg/day until the discharge (a mean of 28 days) after PCI | No NIC administered | LVEF; MACEs | 6 months |
Kawai, 2009 [18] | NIC: 206,161/45 Control: 202,149/53 | 69 (11.1) 71 (11.5) | Patients with/without acute coronary syndrome | 6 mg IV before PCI | No NIC administered | CK-MB;MACEs | 12 months |
Kim, 2005 [24] | NIC: 42,27/15 Control: 54,32/22 | 60.4 (11.7) 61.7 (8.2) | Patients with unstable angina | 4 mg IV before PCI, IV drip infusion (6 mg/hr) for 48 h,oral15 mg/day6 months after PCI | Isosorbide dinitrate | LVEF; MACEs | 6 months |
Kim, 2012 [19] | NIC: 54,36/8 Control: 55,46/9 | 65.5 (7.4) 63.2 (9.2) | Patients with stable or unstable angina | 4 mg ICin 5 min before PCI | No NIC administered | MACEs | 6 months |
Miyoshi, 2017 [13] | NIC: 129,99/30 Control: 133,102/31 | 70.0 (9.2) 70.3 (10.1) | Patients with stable coronary artery disease | 4 mg IV for 5 min at least 1 h before PCI, IV drip infusion (6 mg/h) for at least 8 h after PCI | No NIC administered | MACEs | 8 months |
Murakami, 2006 [26] | NIC: 91,75/16 Control: 101,81/20 | 65.0 (9.7) 66.1 (10.3) | Patients with CHD | IV drip infusion (2 mg/h) for 6 h after PCI | Placebo | CK-MB;cTnI | 3 months- 3.1 years |
Ono, 2004 [20] | NIC: 33,22/11 Control: 25,16/9 | 64 (13) 66 (12) | Patients with AMI | 4 mg IV before PCI, IV drip infusion (8 mg/hr) for 24 h after PCI | No NIC administered | LVEF; MACEs | 6 months |
Yamada, 2015 [14] | NIC: 28,23/5 Control: 24,22/2 | 67 (10) 65 (12) | Patients with AMI | 2 mg IC before PCI, IV drip infusion (2 mg/hr) for 4 days after PCI | Nitrate | LVEF | NR |