Table 2 Two-way interactions between TLR4 and MMP9 polymorphisms in the risk of AAa
TLR4 | Genotypes | Number of Participants | MMP9rs17576 | |||
|---|---|---|---|---|---|---|
GG + GA | AA | GG | AA+GA | |||
AA vs. CON | ||||||
rs11536889 | GG | No. of controls/cases | 290/273 | 18/29 | 161/148 | 147/154 |
|  |  | OR(95% CI) | 1.0(ref.) | 0.917(0.690–1.220) | 1.0(ref.) | 1.140(0.830–1.566) |
|  | GC + CC | No. of controls/cases | 154/133 | 7/16 | 86/75 | 75/74 |
|  |  | OR(95% CI) | 0.917(0.690–1.220) | 2.428(0.984–5.993) | 0.949(0.648–1.390) | 1.073(0.726–1.587) |
|  |  |  | Pinteraction = 0.430, OR = 1.559(0.517–4.701) | Pinteraction = 0.979, OR = 1.007(0.582–1.744) | ||
|  | GG + GC | No. of controls/cases | 419/381 | 25/42 | 232/211 | 212/212 |
|  |  | OR(95% CI) | 1.0(ref.) | 1.848(1.105–3.090) | 1.0(ref.) | 1.100(0.842–1.435) |
| Â | CC | No. of controls/cases | 25/25 | 0/3 | 15/12 | 10/16 |
|  |  | OR(95% CI) | 1.100(0.621–1.947) | NA | 0.880(0.403–1.922) | 1.759(0.781–3.962) |
|  |  |  | Pinteraction = NA, OR = NA | Pinteraction = 0.289, OR = 1.842(0.595–5.700) | ||
rs1927914 | TT | No. of controls/cases | 168/145 | 12/13 | 104/81 | 76/77 |
|  |  | OR(95% CI) | 1.0(ref.) | 1.255(0.555–2.837) | 1.0(ref.) | 1.301(0.846–1.999) |
|  | TC + CC | No. of controls/cases | 268/255 | 14/32 | 138/144 | 144/143 |
|  |  | OR(95% CI) | 1.103(0.833–1.460) | 2.648(1.360–5.156) | 1.340(0.923–1.945) | 1.275(0.880–1.848) |
|  |  |  | Pinteraction = 0.274, OR = 1.797(0.629–5.131) | Pinteraction = 0.253, OR = 0.729(0.424–1.253) | ||
|  | TT + TC | No. of controls/cases | 365/332 | 23/37 | 205/187 | 183/182 |
|  |  | OR(95% CI) | 1.0(ref.) | 1.769(1.029–3.039) | 1.0(ref.) | 1.090(0.820–1.450) |
| Â | CC | No. of controls/cases | 71/68 | 3/8 | 37/38 | 37/38 |
|  |  | OR(95% CI) | 1.053(0.731–1.516) | 2.932(0.771–11.143) | 1.126(0.687–1.845) | 1.126(0.687–1.845) |
|  |  |  | Pinteraction = 0.561, OR = 1.549(0.355–6.766) | Pinteraction = 0.804, OR = 0.915(0.453–1.846) | ||
AA type | ||||||
AAA vs. CON | ||||||
rs11536889 | GG | No. of controls/cases | 290/123 | 18/16 | 161/68 | 147/71 |
|  |  | OR(95% CI) | 1.0(ref.) | 2.096(1.035–4.244) | 1.0(ref.) | 1.144(0.766–1.707) |
|  | GC + CC | No. of controls/cases | 154/56 | 7/9 | 86/34 | 75/31 |
|  |  | OR(95% CI) | 0.857(0.591–1.243) | 3.031(1.104–8.323) | 0.936(0.575–1.525) | 0.979(0.590–1.622) |
|  |  |  | Pinteraction = 0.298, OR = 1.972(0.549–7.086) | Pinteraction = 0.927, OR = 1.034(0.506–2.111) | ||
|  | GG + GC | No. of controls/cases | 419/171 | 25/23 | 232/97 | 212/97 |
|  |  | OR(95% CI) | 1.0(ref.) | 2.254(1.245–4.081) | 1.0(ref.) | 1.094(0.781–1.534) |
| Â | CC | No. of controls/cases | 25/8 | 0/2 | 15/5 | 10/5 |
|  |  | OR(95% CI) | 0.784(0.347–1.773) | NA | 0.797(0.282–2.254) | 1.196(0.398–3.590) |
|  |  |  | Pinteraction = NA, OR = NA | Pinteraction = 0.677, OR = 1.386(0.298–6.443) | ||
rs1927914 | TT | No. of controls/cases | 168/62 | 12/10 | 104/38 | 76/34 |
|  |  | OR(95% CI) | 1.0(ref.) | 2.903(1.325–6.361) | 1.0(ref.) | 1.224(0.707–2.120) |
|  | TC + CC | No. of controls/cases | 268/114 | 14/15 | 138/65 | 144/64 |
|  |  | OR(95% CI) | 1.153(0.801–1.660) | 2.589(0.929–5.489) | 1.289(0.802–2.071) | 1.216(0.757–1.954) |
|  |  |  | Pinteraction = 0.829, OR = 0.876(0.265–2.898) | Pinteraction = 0.468, OR = 0.772(0.384–1.553) | ||
|  | TT + TC | No. of controls/cases | 365/144 | 23/23 | 205/84 | 183/83 |
|  |  | OR(95% CI) | 1.0(ref.) | 2.535(1.378–4.662) | 1.0(ref.) | 1.107(0.770–1.591) |
| Â | CC | No. of controls/cases | 71/32 | 3/2 | 37/19 | 37/15 |
|  |  | OR(95% CI) | 1.142(0.721–1.809) | 1.690(0.279–10.218) | 1.253(0.682–2.303) | 0.989(0.516–1.898) |
|  |  |  | Pinteraction = 0.476, OR = 0.490(0.069–3.476) | Pinteraction = 0.429, OR = 0.694(0.280–1.717) | ||
TAA vs. CON | ||||||
rs11536889 | GG | No. of controls/cases | 290/125 | 18/10 | 161/63 | 147/72 |
|  |  | OR(95% CI) | 1.0(ref.) | 1.289(0.579–2.871) | 1.0(ref.) | 1.252(0.835–1.877) |
|  | GC + CC | No. of controls/cases | 154/66 | 7/5 | 86/35 | 75/36 |
|  |  | OR(95% CI) | 0.994(0.696–1.420) | 1.657(0.516–5.321) | 1.040(0.638–1.696) | 1.227(0.749–2.008) |
|  |  |  | Pinteraction = 0.667, OR = 1.370(0.326–5.764) | Pinteraction = 0.828, OR = 0.926(0.463–1.851) | ||
|  | GG + GC | No. of controls/cases | 419/174 | 25/14 | 232/91 | 212/97 |
|  |  | OR(95% CI) | 1.0(ref.) | 1.349(0.685–2.656) | 1.0(ref.) | 1.166(0.829–1.641) |
| Â | CC | No. of controls/cases | 25/17 | 0/1 | 15/7 | 10/11 |
|  |  | OR(95% CI) | 1.637(0.863–3.109) | NA | 1.190(0.470–3.013) | 2.804(1.152–6.829) |
|  |  |  | Pinteraction = NA, OR = NA | Pinteraction = 0.280, OR = 2.037(0.561–7.405) | ||
rs1927914 | TT | No. of controls/cases | 168/72 | 12/2 | 104/38 | 76/36 |
|  |  | OR(95% CI) | 1.0(ref.) | 0.389(0.085–1.782) | 1.0(ref.) | 1.296(0.753–2.232) |
|  | TC + CC | No. of controls/cases | 268/117 | 14/13 | 138/61 | 144/69 |
|  |  | OR(95% CI) | 1.019(0.717–1.447) | 2.167(0.970–4.840) | 1.210(0.750–1.952) | 1.311(0.820–2.097) |
|  |  |  | Pinteraction = 0.038 (0.076b), OR = 6.186(1.103–34.690) | Pinteraction = 0.609, OR = 0.836(0.421–1.660) | ||
|  | TT + TC | No. of controls/cases | 365/159 | 23/11 | 205/83 | 183/87 |
|  |  | OR(95% CI) | 1.0(ref.) | 1.098(0.523–2.306) | 1.0(ref.) | 1.174(0.819–1.684) |
| Â | CC | No. of controls/cases | 71/30 | 3/4 | 37/16 | 37/18 |
|  |  | OR(95% CI) | 0.970(0.609–1.545) | 3.061(0.677–13.834) | 1.068(0.563–2.024) | 1.202(0.647–2.230) |
|  |  |  | Pinteraction = 0.180, OR = 3.282(0.579–18.608) | Pinteraction = 0.951, OR = 0.972(0.399–2.371) | ||
AA size | ||||||
large AA vs. CON | ||||||
rs11536889 | GG | No. of controls/cases | 290/91 | 18/12 | 161/57 | 147/46 |
|  |  | OR(95% CI) | 1.0(ref.) | 2.125(0.986–4.577) | 1.0(ref.) | 0.884(0.565–1.384) |
|  | GC + CC | No. of controls/cases | 154/45 | 7/6 | 86/29 | 75/22 |
|  |  | OR(95% CI) | 0.931(0.620–1.399) | 2.732(0.895–8.335) | 0.952(0.567–1.599) | 0.829(0.472–1.455) |
|  |  |  | Pinteraction = 0.613, OR = 1.437(0.353–5.842) | Pinteraction = 0.901, OR = 1.051(0.478–2.309) | ||
|  | GG + GC | No. of controls/cases | 419/124 | 25/18 | 232/79 | 212/63 |
|  |  | OR(95% CI) | 1.0(ref.) | 2.433(1.285–4.605) | 1.0(ref.) | 0.873(0.597–1.276) |
| Â | CC | No. of controls/cases | 25/12 | 0/0 | 15/7 | 10/5 |
|  |  | OR(95% CI) | 1.622(0.792–3.322) | NA | 1.370(0.539–3.483) | 1.468(0.487–4.426) |
|  |  |  | Pinteraction = 0.211, OR = 1.591(0.769–3.289) | Pinteraction = 0.756, OR = 1.263(0.290–5.503) | ||
rs1927914 | TT | No. of controls/cases | 168/53 | 12/2 | 104/34 | 76/21 |
|  |  | OR(95% CI) | 1.0(ref.) | 0.528(0.115–2.436) | 1.0(ref.) | 0.845(0.455–1.570) |
|  | TC + CC | No. of controls/cases | 268/82 | 14/16 | 138/54 | 144/44 |
|  |  | OR(95% CI) | 0.970(0.653–1.441) | 3.623(1.659–7.910) | 1.197(0.727–1.971) | 0.935(0.559–1.562) |
|  |  |  | Pinteraction = 0.044(0.088b), OR = 5.892(1.048–33.115) | Pinteraction = 0.881, OR = 0.942(0.431–2.059) | ||
|  | TT + TC | No. of controls/cases | 365/113 | 23/15 | 205/72 | 183/56 |
|  |  | OR(95% CI) | 1.0(ref.) | 2.107(1.063–4.174) | 1.0(ref.) | 0.871(0.583–1.303) |
| Â | CC | No. of controls/cases | 71/22 | 3/3 | 37/16 | 37/9 |
|  |  | OR(95% CI) | 1.001(0.593–1.688) | 3.230(0.643–16.227) | 1.231(0.646–2.347) | 0.693(0.319–1.505) |
|  |  |  | Pinteraction = 0.806, OR = 1.257(0.203–7.796) | Pinteraction = 0.418, OR = 0.653(0.233–1.831) | ||
small AA vs. CON | ||||||
rs11536889 | GG | No. of controls/cases | 290/159 | 18/16 | 161/82 | 147/93 |
|  |  | OR(95% CI) | 1.0(ref.) | 1.621(0.805–3.267) | 1.0(ref.) | 1.242(0.857–1.801) |
|  | GC + CC | No. of controls/cases | 154/78 | 7/9 | 86/40 | 75/47 |
|  |  | OR(95% CI) | 0.924(0.661–1.290) | 2.345(0.857–6.416) | 0.913(0.577–1.446) | 1.230(0.784–1.932) |
|  |  |  | Pinteraction = 0.475, OR = 1.572(0.454–5.446) | Pinteraction = 0.838, OR = 1.070(0.562–2.034) | ||
|  | GG + GC | No. of controls/cases | 419/225 | 25/22 | 232/118 | 212/129 |
|  |  | OR(95% CI) | 1.0(ref.) | 1.639(0.904–2.972) | 1.0(ref.) | 1.196(0.876–1.634) |
| Â | CC | No. of controls/cases | 25/12 | 0/3 | 15/4 | 10/11 |
|  |  | OR(95% CI) | 0.894(0.441–1.813) | NA | 0.524(0.170–1.615) | 2.163(0.893–5.238) |
|  |  |  | Pinteraction = NA, OR = NA | Pinteraction = 0.093, OR = 3.411(0.814–14.288) | ||
rs1927914 | TT | No. of controls/cases | 168/81 | 12/11 | 104/41 | 76/51 |
|  |  | OR(95% CI) | 1.0(ref.) | 1.901(0.805–4.493) | 1.0(ref.) | 1.702(1.026–2.825) |
|  | TC + CC | No. of controls/cases | 268/151 | 14/14 | 138/80 | 144/85 |
|  |  | OR(95% CI) | 1.169(0.839–1.628) | 2.074(0.944–4.555) | 1.470(0.933–2.316) | 1.497(0.955–2.348) |
|  |  |  | Pinteraction = 0.927, OR = 0.947(0.298–3.008) | Pinteraction = 0.116, OR = 0.600(0.318–1.134) | ||
|  | TT + TC | No. of controls/cases | 365/194 | 23/21 | 205/100 | 183/115 |
|  |  | OR(95% CI) | 1.0(ref.) | 1.718(0.927–3.183) | 1.0(ref.) | 1.288(0.922–1.799) |
| Â | CC | No. of controls/cases | 71/38 | 3/4 | 37/21 | 37/21 |
|  |  | OR(95% CI) | 1.007(0.655–1.549) | 2.509(0.556–11.322) | 1.164(0.647–2.091) | 1.164(0.647–2.091) |
|  |  |  | Pinteraction = 0.629, OR = 1.508(0.284–8.002) | Pinteraction = 0.561, OR = 0.782(0.342–1.791) | ||