Table 2 Results of overall and subgroup analyses for ADIPOQ polymorphisms and CAD
From: Associations between ADIPOQ polymorphisms and coronary artery disease: a meta-analysis
Population | Sample size | Dominant comparison | Recessive comparison | Overdominant comparison | Allele comparison |
|---|---|---|---|---|---|
P value OR (95%CI) I2 statistic | P value OR (95%CI) I2 statistic | P value OR (95%CI) I2 statistic | P value OR (95%CI) I2 statistic | ||
rs1501299 G/T | GG vs. GT + TT | TT vs. GG + GT | GT vs. GG + TT | G vs. T | |
Overall | 11,544/15642 | 0.30 0.94 (0.84–1.05) 73% | 0.42 0.94 (0.80–1.10) 57% | 0.08 1.09 (0.99–1.19) 60% | 0.71 0.98 (0.90–1.08) 76% |
Caucasian | 5481/5107 | 0.82 1.01 (0.93–1.09) 39% | 0.12 0.80 (0.61–1.06) 67% | 0.29 1.04 (0.96–1.13) 2% | 0.47 1.04 (0.93–1.17) 64% |
East Asian | 4074/7814 | 0.08 0.82 (0.66–1.03) 82% | 0.03 1.20 (1.02–1.42) 40% | 0.10 1.18 (0.97–1.43) 76% | 0.14 0.88 (0.74–1.04) 80% |
South Asian | 479/645 | 0.88 1.04 (0.61–1.77) 78% | 0.97 0.99 (0.68–1.45) 42% | 0.79 0.95 (0.65–1.38) 55% | 0.90 1.03 (0.68–1.56) 80% |
MI | 4159/5883 | 0.67 1.04 (0.87–1.23) 65% | 0.63 0.91 (0.63–1.32) 74% | 0.42 0.96 (0.88–1.05) 47% | 0.71 1.03 (0.88–1.21) 75% |
rs2241766 T/G | TT vs. TG + GG | GG vs. TT + TG | TG vs. TT + GG | T vs. G | |
Overall | 10,135/11577 | 0.0009 0.82 (0.73–0.92) 67% | 0.04 1.29 (1.02–1.64) 63% | 0.08 1.12 (0.99–1.27) 71% | < 0.0001 0.80 (0.73–0.88) 67% |
Caucasian | 2771/2106 | 0.09 0.89 (0.79–1.02) 27% | 0.39 0.87 (0.62–1.20) 0% | 0.04 1.15 (1.01–1.32) 33% | 0.24 0.93 (0.84–1.05) 20% |
East Asian | 4856/6280 | 0.02 0.80 (0.66–0.96) 77% | 0.06 1.35 (0.99–1.84) 68% | 0.30 1.12 (0.90–1.40) 83% | 0.0006 0.80 (0.71–0.91) 66% |
South Asian | 959/960 | 0.04 0.69 (0.48–0.99) 66% | < 0.0001 2.67 (1.82–3.91) 39% | 0.76 1.05 (0.76–1.46) 56% | 0.01 0.64 (0.45–0.91) 76% |
MI | 1869/1407 | 0.19 0.90 (0.77–1.05) 0% | 0.11 0.68 (0.43–1.09) 18% | 0.06 1.16 (0.99–1.36) 30% | 0.48 0.95 (0.83–1.09) 0% |