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Table 3 Predictors of ischemic stroke in a multivariable Cox regression model (n = 42,478)

From: Increase in ticagrelor use over time is associated with lower rates of ischemic stroke following myocardial infarction

Variable

HR (95% CI)

P-value

Age 65–74 yearsa

1.65 (1.34–2.03)

< 0.001

Age ≥ 75 years

2.18 (1.78–2.68)

< 0.001

STEMIb

1.27 (1.11–1.46)

< 0.001

Diabetes

1.23 (1.07–1.41)

< 0.01

Hypertension

1.17 (1.02–1.35)

0.03

Atrial fibrillation

1.92 (1.68–2.2)

< 0.001

Heart failure during hospitalization

1.29 (1.27–1.48)

< 0.001

PCIc during hospitalization

0.72 (0.63–0.83)

< 0.001

CABGd during hospitalization

1.93 (1.28–2.9)

< 0.01

Previous ischemic stroke

3.12 (2.7–3.62)

< 0.001

Previous hemorrhagic stroke

1.54 (1.07–2.21)

0.02

Statins at discharge

0.8 (0.67–0.94)

0.01

eGFRe

0.996 (0.993–0.999)

0.01

Belonging to the late cohort

0.87 (0.77–0.99)

0.03

  1. aAge ≤ 64 years as reference for the different age categories
  2. bST-elevation myocardial infarction
  3. cPercutaneous coronary intervention
  4. dCoronary artery bypass graft surgery
  5. eEstimated glomerular filtration rate