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Table 3 Predictors of ischemic stroke in a multivariable Cox regression model (n = 42,478)

From: Increase in ticagrelor use over time is associated with lower rates of ischemic stroke following myocardial infarction

Variable HR (95% CI) P-value
Age 65–74 yearsa 1.65 (1.34–2.03) < 0.001
Age ≥ 75 years 2.18 (1.78–2.68) < 0.001
STEMIb 1.27 (1.11–1.46) < 0.001
Diabetes 1.23 (1.07–1.41) < 0.01
Hypertension 1.17 (1.02–1.35) 0.03
Atrial fibrillation 1.92 (1.68–2.2) < 0.001
Heart failure during hospitalization 1.29 (1.27–1.48) < 0.001
PCIc during hospitalization 0.72 (0.63–0.83) < 0.001
CABGd during hospitalization 1.93 (1.28–2.9) < 0.01
Previous ischemic stroke 3.12 (2.7–3.62) < 0.001
Previous hemorrhagic stroke 1.54 (1.07–2.21) 0.02
Statins at discharge 0.8 (0.67–0.94) 0.01
eGFRe 0.996 (0.993–0.999) 0.01
Belonging to the late cohort 0.87 (0.77–0.99) 0.03
  1. aAge ≤ 64 years as reference for the different age categories
  2. bST-elevation myocardial infarction
  3. cPercutaneous coronary intervention
  4. dCoronary artery bypass graft surgery
  5. eEstimated glomerular filtration rate