Increase in ticagrelor use over time is associated with lower rates of ischemic stroke following myocardial infarction

Table 1 Baseline characteristics and medication at discharge, early vs. late cohort

	Early (n = 23,447)	Late (n = 24,227)	P-value
Age (median)	70 (61–79)	70 (61–79)	0.08
Women%	33.5	33.7	0.89
Smoking%	23.1	22.2	0.02
Diabetes%	21.7	22.3	0.12
STEMI^a%	36.9	37	0.9
Hypertension%	53	54.6	<0.001
Atrial fibrillation%	13.9	14.1	0.38
Heart failure during hospitalization%	20.2	18.9	<0.001
Previous MI^b%	8.5	7.3	< 0.001
Previous ischemic stroke%	7.0	6.8	0.42
Previous hemorrhagic stroke%	1.1	1.3	0.08
Previous dialysis%	0.5	0.5	0.96
Previous PAD^c%	4.4	4.9	0.03
Thrombolysis during hospitalization%	1.7	1.2	<0.001
PCI^d during hospitalization%	71.1	75.4	<0.001
CABG^e during hospitalization%	1.1	1.4	< 0.001
eGFR^f	77.7 (60–90.8)	78.1 (60.2–91.2)	0.06
Aspirin	97	95.6	<0.001
ACEI/ARB^g	78.6	79.8	<0.01
Statins	91.1	91.5	0.14
Oral anticoagulants	4.5	6.3	<0.001
Beta blockers	90.5	89.1	<0.001
Calcium inhibitors	15.3	16.2	0.01
Diuretics	26.4	23.5	<0.001

^aST-elevation myocardial Infarction
^bMyocardial infarction
^cPeripheral artery disease
^dPercutaneous coronary intervention
^eCoronary artery bypass graft surgery
^fEstimated glomerular filtration rate
^gACEI Angiotensin converting enzyme-inhibitors, ARB Angiotensin receptor blockers

ISSN: 1471-2261