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Table 1 ORs (95% confidence intervals) for the associations between socioeconomic and demographic factors and first anticoagulant prescription among patients with NVAF

From: Sociodemographic factors and choice of oral anticoagulant in patients with non-valvular atrial fibrillation in Sweden: a population-based cross-sectional study using data from national registers

Patient characteristic NOAC Warfarin Crude OR (95% CI) Age- and sex-adjusted OR (95% CI) Multivariable adjusted ORa (95% CI)
N = 18,638 N = 49,418
Sex
 Men 10,144 (54.4) 27,198 (55.0) 1.0 (ref) 1.0 (ref) 1.0 (ref)
 Women 8494 (45.6) 22,220 (45.0) 1.02 (0.99–1.06) 1.04 (1.01–1.08) 1.05 (1.01–1.10)
Age (years)
 Mean ± SD 74.4 ± 11.1 73.7 ± 10.7    
 18–54 964 (5.2) 2431 (4.9) 0.98 (0.91–1.06) 0.99 (0.91–1.07) 0.88 (0.80–0.97)
 55–64 2488 (13.4) 6151 (12.5) 1.00 (0.95–1.06) 1.00 (0.95–1.06) 0.95 (0.88–1.02)
 65–74 6456 (34.6) 15,969 (32.3) 1.0 (ref) 1.0 (ref) 1.0 (ref)
 75–84 5630 (30.2 17,143 (34.7) 0.81 (0.78–0.85) 0.81 (0.78–0.84) 0.85 (0.81–0.90)
 ≥85 3100 (16.6) 7724 (15.6) 0.99 (0.94–1.04) 0.98 (0.93–1.03) 0.91 (0.85–0.97)
Regionb
 Urban 9181 (49.5) 23,608 (47.9) 1.0 (ref) 1.0 (ref) 1.0 (ref)
 South 3741 (20.2) 9821 (19.9 0.98 (0.94–1.02) 0.98 (0.94–1.03) 1.05 (1.00–1.14)
 Mid 3721 (20.1) 6455 (13.1) 1.48 (1.41–1.55) 1.48 (1.41–1.55) 1.67 (1.59–1.77)
 North 1890 (10.2) 9365 (19) 0.52 (0.49–0.55) 0.52 (0.49–0.55) 0.48 (0.45–0.51)
Education (years)
 ≤9 6615 (35.5) 19,898 (40.3) 1.0 (ref) 1.0 (ref) 1.0 (ref)
 9–12 6911 (37.1) 18,788 (38) 1.10 (1.06–1.15) 1.10 (1.06–1.15) 1.09 (1.04–1.14)
 ≥13 4785 (25.7) 9968 (20.2) 1.44 (1.38–1.51) 1.44 (1.38–1.51) 1.37 (1.30–1.45)
 Missing 327 (1.8) 764 (1.6) 1.29 (1.13–1.47) 1.28 (1.13–1.47) 1.20 (1.00–1.43)
Occupation
 Not working (retired/unemployed) 13,765 (73.9) 38,873 (78.7) 1.0 (ref) 1.0 (ref) 1.0 (ref)
 Higher clerk/ leading position 850 (4.6) 1357 (2.8) 1.77 (1.62–1.93) 1.97 (1.80–2.17) 1.41 (1.27–1.58)
 Qualified white collar 1072 (5.8) 2077 (4.2) 1.46 (1.35–1.57) 1.60 (1.48–1.74) 1.20 (1.09–1.32)
 Other white collar 430 (2.3) 959 (1.9) 1.27 (1.13–1.42) 1.39 (1.24–1.57) 1.06 (0.92–1.26)
 Self-employed excl. Farmers 648 (3.5) 1548 (3.1 1.18 (1.08–1.30) 1.28 (1.16–1.42) 1.16 (1.04–1.30)
 Farmer 201 (1.1) 550 (1.1) 1.03 (0.88–1.21) 1.12 (0.95–1.32) 1.03 (0.86–1.24)
 Foreman/technician 37 (0.2) 60 (0.1) 1.74 (1.16–2.62) 1.96 (1.30–2.96) 1.74 (1.10–2.75)
 Skilled within trade, service or care 494 (2.7) 1289 (2.6) 1.08 (0.97–1.20) 1.18 (1.06–1.32) 0.97 (0.85–1.10)
 Skilled blue collar worker 360 (1.9) 900 (1.8) 1.13 (1.00–1.28) 1.29 (1.13–1.47) 1.04 (0.90–1.21)
 Other blue collar worker 635 (3.4) 1566 (3.2) 1.15 (1.04–1.26) 1.29 (1.17–1.43) 1.08 (0.96–1.21)
 Missing 146 (0.8) 239 (0.5) 1.72 (1.40–2.12) 1.87 (1.52–2.30) 1.62 (1.04–2.51)
Income (SEK) c
 Mean (1000s) ± SD 232 ± 505 209 ± 296    
 Quartile 1 4275 (22.9) 12,557 (25.4) 1.0 (ref) 1.0 (ref) 1.0 (ref)
 Quartile 2 4411 (23.7) 12,806 (25.9) 1.01 (0.96–1.06) 1.02 (0.97–1.07) 1.00 (0.95–1.06)
 Quartile 3 4490 (24.1) 12,499 (25.3) 1.06 (1.01–1.11) 1.09 (1.04–1.15) 1.02 (0.96–1.08)
 Quartile 4 5462 (29.3) 11,556 (23.4) 1.39 (1.32–1.46) 1.46 (1.38–1.53) 1.23 (1.16–1.31)
Immigrant status
 Swedish background 16,503 (88.5) 43,930 (88.9) 1.0 (ref)
 Foreign background 2135 (11.5) 5488 (11.1) 1.04 (0.98–1.09)
  1. Data are n (%) unless otherwise specified
  2. aAdjusted for sex, age, region, educational level, type of employment, disposable income, number of years since first AF diagnosis, calendar year of inclusion in the study, previous hospitalization for bleeding, anaemia, myocardial infarction, heart failure, valvular disease (other than the exclusion criteria), pacemaker or ICD, diabetes, chronic kidney disease, chronic obstructive pulmonary disease, alcohol index, dementia, hospitalization for falls occurring more than once and use of the following drugs < 6 months before the index date: beta blockers, digoxin, class 1 antiarrhthmic drugs and sotalol
  3. bUrban = Stockholm, Malmö and Göteborg; South = Götaland; Mid = Svealand; North = Norrland
  4. cQuartile 1 = < 130,000 SEK; Quartile 2 = 130,000–165,000 SEK; Quartile 3 = 165,000–238,000 SEK; Quartile 4 = ≥238,000 SEK)
  5. CI confidence interval, NVAF non-valvular atrial fibrillation, OR odds ratio, SD standard deviation, SEK Swedish Krona