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Table 2 Change in coronary plaque composition over serial CCTA

From: Progression of coronary atherosclerotic plaque burden and relationship with adverse cardiovascular event in asymptomatic diabetic patients

Patients (n = 197) Patients with CACS ≤10 Patients with CACS > 10 P value
Baseline Repeat Δ-Value Baseline Repeat Δ-Value
Total lumen vol. 125.5 (±113.7) 125.48 (±107.0) 2.95 (±67.8) 182.3 (±131.8) 194.0 (±141.8) 10.8 (±110.3) 0.060
Total plaque vol. 85.8 (±89.4) 104.4 (±106.5) 20.6 (±63.5) 102.1 (±83.4) 132.1 (±116.5) 30.1 (±102.6) 0.002
PAV, % (±SD) 39.3 (±16.4) 44.0 (±16.4) 5.7 (±13.9) 34.7 (±12.8) 38.9 (±12.7) 4.2 (±13.6) 0.676
Total dense calcium
 Mean (±SD) 6.7 (±18.9) 6.8 (±16.4) 0.3 (±13.6) 23.1 (±28.0) 28.8 (±35.9) 5.7 (±28.5) 0.002
 Median [IQR] 0 [0, 5.2] 0 [0,8.2] 0 [0,2.5] 12.2 [6.5,28.0] 17.2 [7.6,31.1] 1.43 [−0.81,4.11] 0.387
 PAV, % (±SD) 2.5 (±4.5) 3.0 (±5.2) 0.6 (±2.5) 8.0 (±7.5) 9.1 (±8.8) 1.1 (±4.4) 0.360
Total fibrotic vol.
 Mean (±SD) 63.5 (±61.9) 71.1 (±63.0) 9.2 (±40.6) 65.1 (±49.5) 77.8 (±62.9) 12.6 (±53.3) 0.029
 PAV, % (±SD) 30.9 (±14.2) 31.7 (±13.0) 0.9 (±12.9) 22.9 (±10.5) 23.7 (±11.3) 0.7 (±10.7) 0.70
Total low attenuation vol.
 Mean (±SD) 15.9 (±25.9) 29.7 (±49.6) 14.3(±34.9) 14.6 (±20.9) 25.5 (±35.0) 10.9 (±34.1) 0.018
 PAV, % (±SD) 6.7 (±7.9) 10.2 (±10.0) 3.6 (±7.9) 4.3 (±4.7) 6.2 (±6.6) 1.8 (±7.4) 0.850
  1. Continuous variables are presented as mean (±SD) and median [IQR] for the dense calcium volume. Percent Atheroma Volume (PAV) is presented as percentages. Volumes (Vol.) are measured in mm3. Differences between delta (Δ) values were tested with a student’s t-test (p) in normal distributed variables and in non-normal distributed variables with the non-parametric Kruskal-Wallis test (p*)