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Table 3 Association between serum IL8 levels and risk of all cause, CVD and cancer related mortality expressed as hazard ratios (HR), 95% confidence intervals (CI)

From: Serum IL8 is not associated with cardiovascular events but with all-cause mortality

  IL8Q1 IL8Q2 p IL8Q3 p IL8Q4 p
All-cause mortality (n = 647) 869/127 849/153   843/178   803/189  
 Crude (n = 4011) 1 1.21 (0.95–1.53) 0.11 1.40 (1.11–1.76) 0.004 1.54 (1.23–1.93) < 0.0001
 Model 1a (n = 3845) 1 1.13 (0.89–1.45) 0.30 1.34 (1.06–1.70) 0.01 1.35 (1.07–1.71) 0.01
 Model 1b (n = 3837) 1 1.09 (0.85–1.39) 0.38 1.27 (1.01–1.62) 0.04 1.28 (1.02–1.63) 0.03
CVD related mortality (n = 136) 885/24 881/38   878/32   868/42  
 Crude (n = 3648) 1 1.58 (0.95–2.64) 0.07 1.35 (0.79–2.29) 0.26 1.80 (1.01–2.97) 0.02
 Model 1a (n = 3509) 1 1.48 (0.80–2.32) 0.15 1.35 (0.77–2.36) 0.28 1.48 (0.87–2.53) 0.14
 Model 1b (n = 3504) 1 1.37 (0.79–2.38) 0.25 1.24 (0.71–2.17) 0.44 1.35 (0.79–2.32) 0.26
Cancer related mortality (n = 266) 906/55 903/68   934/64   887/79  
 Crude (n = 3896) 1 1.23 (0.89–1.78) 0.18 1.15 (0.80–1.65) 0.44 1.46 (1.04–2.07) 0.03
 Model 1a (n = 3732) 1 1.18 (0.82–1.71) 0.36 1.09 (0.75–1.59) 0.62 1.27 (0.89–1.82) 0.18
 Model 1b (n = 3724) 1 1.15 (0.79–1.66) 0.45 1.06 (0.73–1.53) 0.75 1.23 (0.86–1.77) 0.24
  1. Numbers of study participants is reported for the crude model. Missing values in the confounders are specified in Table 1. Model 1a: adjusted by sex, smoking, alcohol consumption, physical activity at work and during leisure time; Model 1b: model 1a + systolic and diastolic blood pressure, central obesity, cholesterol and glucose levels