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Table 2 Association between serum IL8 levels with the risk of first CVE and CVD related death expressed as hazard ratios (HR), 95% confidence intervals (CI)

From: Serum IL8 is not associated with cardiovascular events but with all-cause mortality

 

IL8Q1

IL8Q2

p

IL8Q3

p

IL8Q4

p

CVE (n = 522)

776/125

782/127

 

776/128

 

765/142

 

Crude (n = 3626)

1

1.01 (0.78–1.29)

0.94

1.03 (0.80–1.31)

0.81

1.15 (0.90–1.46)

0.24

Model 1 (n = 3583)

1

0.98 (0.76–1.25)

0.87

0.94 (0.73–1.20)

0.63

0.96 (0.75–1.22)

0.74

MI and angina requiring hospitalization (n = 358)

778/91

783/82

 

779/94

 

764/91

 

Crude (n = 3462)

1

0.90 (0.67–1.21)

0.51

1.03 (0.78–1.38)

0.80

1.03 (0.77–1.38)

0.82

Model 1 (n = 3417)

1

0.88 (0.65–1.20)

0.44

0.93 (0.70–1.24)

0.63

0.83 (0.62–1.24)

0.23

Ischemic stroke (n = 164)

778/34

783/45

 

779/33

 

764/52

 

Crude (n = 3462)

1

1.30 (0.83–2.03)

0.24

0.97 (0.60–1.57)

0.91

1.55 (1.01–2.40)

0.04

Model 1 (n = 3226)

1

1.24 (0.79–1.94)

0.34

0.91 (0.56–1.48)

0.73

1.37 (0.88–2.12)

0.15

  1. Number of study participants in each IL8 quartile refers to the crude model. Ischemic stroke cases (n = 164) were excluded from the analysis of the association of IL8 with the risk of MI and angina requiring hospitalization. MI and angina requiring hospitalization (n = 358) were excluded from the analysis of the association of IL8 with the risk of ischemic stroke. Missing values in the confounders are specified in Table 1
  2. Model 1: adjusted by sex, smoking, diabetes, hypercholesterolemia, hypertension, diabetes and central obesity