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Table 2 Association between serum IL8 levels with the risk of first CVE and CVD related death expressed as hazard ratios (HR), 95% confidence intervals (CI)

From: Serum IL8 is not associated with cardiovascular events but with all-cause mortality

  IL8Q1 IL8Q2 p IL8Q3 p IL8Q4 p
CVE (n = 522) 776/125 782/127   776/128   765/142  
Crude (n = 3626) 1 1.01 (0.78–1.29) 0.94 1.03 (0.80–1.31) 0.81 1.15 (0.90–1.46) 0.24
Model 1 (n = 3583) 1 0.98 (0.76–1.25) 0.87 0.94 (0.73–1.20) 0.63 0.96 (0.75–1.22) 0.74
MI and angina requiring hospitalization (n = 358) 778/91 783/82   779/94   764/91  
Crude (n = 3462) 1 0.90 (0.67–1.21) 0.51 1.03 (0.78–1.38) 0.80 1.03 (0.77–1.38) 0.82
Model 1 (n = 3417) 1 0.88 (0.65–1.20) 0.44 0.93 (0.70–1.24) 0.63 0.83 (0.62–1.24) 0.23
Ischemic stroke (n = 164) 778/34 783/45   779/33   764/52  
Crude (n = 3462) 1 1.30 (0.83–2.03) 0.24 0.97 (0.60–1.57) 0.91 1.55 (1.01–2.40) 0.04
Model 1 (n = 3226) 1 1.24 (0.79–1.94) 0.34 0.91 (0.56–1.48) 0.73 1.37 (0.88–2.12) 0.15
  1. Number of study participants in each IL8 quartile refers to the crude model. Ischemic stroke cases (n = 164) were excluded from the analysis of the association of IL8 with the risk of MI and angina requiring hospitalization. MI and angina requiring hospitalization (n = 358) were excluded from the analysis of the association of IL8 with the risk of ischemic stroke. Missing values in the confounders are specified in Table 1
  2. Model 1: adjusted by sex, smoking, diabetes, hypercholesterolemia, hypertension, diabetes and central obesity