HR | 95% CI | p value | |
---|---|---|---|
Demographics | |||
Age | 1.00 | (0.99 - 1.01) | 0.67 |
Female sex | 0.92 | (0.61 - 1.40) | 0.70 |
Dependent living | 0.93 | (0.72 - 1.20) | 0.56 |
Clinical Characteristics | |||
NYHA class | |||
I/II | reference | ||
III | 1.15 | (0.83 - 1.61) | 0.40 |
IV | 1.68 | (1.06 - 2.66) | 0.03 |
Frailty | 0.87 | (0.66 - 1.13) | 0.30 |
Cardiac comorbidities and interventions | |||
Atrial fibrillation | 1.30 | (1.02 - 1.65) | 0.03 |
Prior heart failure | 1.02 | (0.83 - 1.26) | 0.84 |
Prior myocardial infarction | 0.97 | (0.68 - 1.39) | 0.87 |
PCI | 1.02 | (0.73 - 1.43) | 0.92 |
CABG | 0.96 | (0.76 - 1.22) | 0.73 |
Medical comorbidities | |||
Diabetes | 0.96 | (0.63 - 1.48) | 0.86 |
Cerebrovascular disease | 0.70 | (0.50 - 0.98) | 0.04 |
Peripheral vascular disease | 1.27 | (1.02 - 1.57) | 0.03 |
Dementia | 1.03 | (0.60 - 1.78) | 0.90 |
Dialysis | 2.01 | (0.90 - 4.48) | 0.09 |
Lung disease | 1.33 | (1.08 - 1.65) | 0.01 |
Liver disease | 1.52 | (0.43 - 5.36) | 0.51 |
Peptic ulcer disease | 1.86 | (1.29 - 2.67) | <0.001 |
History of bleeding | 1.08 | (0.79 - 1.47) | 0.63 |
Laboratory markers | |||
eGFR | 0.99 | (0.99 - 1.00) | 0.14 |
Hemoglobin | 0.99 | (0.99 - 1.00) | <0.001 |
Echocardiographic findings | |||
Left ventricular dysfunction | 0.76 | (0.57 - 1.02) | 0.07 |
Procedural characteristics | |||
Urgent procedure | 1.10 | (0.66 - 1.81) | 0.72 |
Valve in valve | 0.49 | (0.29 - 0.83) | 0.01 |
Self-expandable prosthesis | 1.15 | (0.89 - 1.48) | 0.29 |
Non-femoral vascular access site | 1.17 | (0.78 - 1.75) | 0.44 |
TAVR year | 0.99 | (0.90 - 1.10) | 0.90 |
Procedural complications | |||
Stroke | 1.78 | (1.22 - 2.60) | 0.003 |
Permanent pacemaker | 0.97 | (0.53 - 1.76) | 0.91 |
Delirium | 1.40 | (0.95 - 2.06) | 0.09 |
Bleeding, vascular complication or transfusion | 1.29 | (1.22 - 1.37) | <0.001 |
Echocardiographic findings post-TAVR | |||
Mitral regurgitation | |||
Nil/trace | reference | ||
Mild | 1.06 | (0.95 - 1.20) | 0.30 |
Moderate/Severe | 1.27 | (0.97 - 1.66) | 0.08 |
Aortic regurgitation | |||
Nil/trace | reference | ||
Mild | 1.25 | (0.95 - 1.64) | 0.11 |
Moderate/Severe | 1.29 | (0.77 - 2.15) | 0.34 |
Previous health resource utilization | |||
Hospitalization 30 days before TAVR | 1.21 | (0.91 - 1.61) | 0.20 |
Transitional care factors in first 30 days | |||
Rehabilitation | 1.55 | (1.37 - 1.75) | <0.001 |
Home care | 0.94 | (0.78 - 1.13) | 0.51 |
Family physician follow-up | 0.73 | (0.51 - 1.05) | 0.09 |
Cardiologist follow-up | 1.13 | (0.89 - 1.42) | 0.32 |