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Table 2 List of related SNPs. Summary of SNPs with lowest p-values, influencing known gene loci for each complication, adjusted for each complication

From: Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study

Chr

SNP

Base pair

Gene symbol

Gene

P value

OR with 95% CI

OR_L95

OR_U95

complication

2

rs7557600

48,772,202

STON1

Stonin1, may be involved in the endocytic machinery

7.25e-07

0.49

0.37

0.65

AFF

3

rs115155878

114,055,988

ZBTB20

Zinc finger and BTB domain containing 20, may be a transcription factor that may be involved in hematopoiesis, oncogenesis and immune response

8.45e-07

0.21

0.11

0.39

AFF

13

rs9563027

51,708,406

LINC00371

Long intergenic non-protein coding RNA 371

9.82e-07

0.56

0.45

0.71

AFF

5

rs4574581

89,925,895

GPR98

G protein-coupled receptor 98, receptor that may have an important role in the development of the central nervous system

2.43e-06

0.54

0.42

0.70

AFF

2

rs13008718

65,961,565

AC074391.1

lincRNA

9.99e-07

0.45

0.33

0.62

DELIR

14

rs188623516

46,926,170

LINC00871

Long intergenic non-protein coding RNA 871

4.02e-06

0.02

0.00

0.10

DELIR

3

rs727476

60,316,417

FHIT

Fragile histidine triad

1.70e-06

0.46

0.33

0.63

MI

7

rs9690969

40,541,259

SUGCT

Succinyl-CoA-glutarate-CoA-transferase

1.19e-06

0.44

0.31

0.61

MI

16

rs78064607

71,723,181

PHLPP2

PH domain and leucine rich repeat protein phosphatase 2, plays a crucial role after I/R injury in the brain and oxidative stress injury in the kidney.

3.77e-08

0.02

0.01

0.09

RENFAIL

8

rs189437718

134,655,419

SNORA40

Small nucleolar RNA, H/ACA Box 40

3.60e-07

0.05

0.01

0.15

RENFAIL

1

rs72654815

21,354,625

EIF4G3

Eukaryotic Translation Initiation Factor 4 Gamma 3

6.79e-07

0.11

0.05

0.27

RENFAIL

11

rs77876049

122,936,811

HSPA8

Heat shock protein 8, HSPA8 seems to play an important role in the regulation of cellular processes after I/R injury both in the heart and in the brain.

9.14e-06

0.25

0.14

0.46

RENFAIL

7

rs79995619

33,511,328

BBS9

Bardet-Biedl Syndrome 9, mutations in this genes are associated with the Bardet-Biedl syndrome, which is characterized by renal failure

3.35e-07

0,001

0.00

0.06

STROKE

3

rs181832941

189,567,428

TP63

Tumor protein p63

3.65e-07

0.01

0.00

0.06

STROKE

18

rs140914711

41,414,229

RNU6-443P

RNA, U6 small nuclear 443, pseudogene

4.07e-07

0.04

0.01

0.13

STROKE

1

rs192540202

237,511,541

RYR2

Ryanodine receptor 2, calcium channel in the myocard muscle

6.33e-07

0.02

0.00

0.08

STROKE

  1. Bold: genes with supposed association to I/R injury