Fig. 2From: A novel TAB2 nonsense mutation (p.S149X) causing autosomal dominant congenital heart defects: a case report of a Chinese familyAnalysis of protein domains and the mutation of TAB2. Schematic representation of TAB2 protein domains indicate an N-terminal coupling of ubiquitin conjugation to endoplasmic reticulum (CUE) domain and a C-terminal TAK1 binding domain (TAK1 BD). The affected amino acid S149, indicated by red arrow, is highly conserved in different speciesBack to article page