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Table 1 Clinical characteristics and circulating biomarkers in study participants

From: Progression of endothelial dysfunction, atherosclerosis, and arterial stiffness in stable kidney transplant patients: a pilot study

ParameterHealthy controls (n = 17)Kidney transplant patients (n = 18)Between-group comparison
BaselineSecond visitP-valueBaselineSecond visitP-valueBaseline results P-value
Age (years)45.82 ± 10.85NANA51.28 ± 13.29NANA0.19
Gender M/F5/12NANA9/9NANA0.21
Body mass index (kg/m2)24.59 ± 2.5925.00 ± 2.660.0925.56 ± 5.1824.03 ± 7.630.360.49
Waist/Hip0.82 ± 0.070.80 ± 0.060.100.86 ± 0.100.93 ± 0.140.070.16
Systolic blood pressure (mmHg)125.53 ± 12.39119.76 ± 10.620.02131.94 ± 11.79130.44 ± 10.200.610.13
Diastolic blood pressure (mmHg)77.24 ± 7.6176.24 ± 8.700.6482.17 ± 9.2280.56 ± 7.450.400.10
Smoking status past/present/never0/6/11NANA0/4/14NANA0.39
Diabetes mellitus0NANA3NANA0.08
History of IHD0NANA0NANANA
Dyslipidaemia3NANA10NANA0.02
Haemoglobin (g/L)134.29 ± 11.86138.71 ± 9.310.02135.33 ± 18.01135.72 ± 15.110.850.84
Albumin (g/L)39.35 ± 2.4740.12 ± 2.320.1938.11 ± 2.7238.83 ± 2.960.340.17
Urea (mmol/L)4.26 ± 0.954.60 ± 1.110.167.31 ± 2.157.83 ± 2.670.05< 0.01
Creatinine (mcmol/L)69.65 ± 16.6369.65 ± 15.661.00104.39 ± 33.68108.94 ± 31.530.14< 0.01
eGFR (mL/min/1.73m2)97.59 ± 15.5997.29 ± 15.550.8367.61 ± 20.2561.56 ± 19.700.02< 0.01
Total cholesterol (mmol/L)5.14 ± 1.135.34 ± 1.210.164.54 ± 0.964.84 ± 1.450.300.10
HDL (mmol/L)1.71 ± 0.561.75 ± 0.620.511.69 ± 0.551.73 ± 0.580.300.92
LDL (mmol/L)3.24 ± 1.713.07 ± 0.890.632.29 ± 0.852.56 ± 1.250.290.04
Total cholesterol/HDL3.29 ± 1.273.32 ± 1.260.783.00 ± 1.283.03 ± 1.180.840.50
Non-HDL (mmol/L)3.44 ± 1.043.60 ± 1.040.092.85 ± 1.063.11 ± 1.370.340.11
Triglyceride (mmol/L)1.05 ± 0.581.05 ± 0.700.971.24 ± 0.721.32 ± 0.740.550.56
Glucose (mmol/L)4.71 ± 0.394.82 ± 0.400.355.74 ± 1.035.69 ± 1.340.80< 0.01
Corrected calcium (mmol/L)2.35 ± 0.052.39 ± 0.070.032.46 ± 0.082.46 ± 0.070.86< 0.01
Inorganic phosphate (mmol/L)1.11 ± 0.131.17 ± 0.140.050.99 ± 0.191.04 ± 0.190.140.03
PTH (pmol/L)4.98 ± 1.574.53 ± 1.090.198.38 ± 3.689.42 ± 6.460.31< 0.01
Vitamin D (nmol/L)43.65 ± 22.0367.41 ± 30.41< 0.0157.56 ± 25.2166.50 ± 27.040.040.09
Troponin T (ng/L)2.35 ± 1.462.76 ± 1.720.138.33 ± 4.948.39 ± 4.850.91< 0.01
NT-pro-BNP (ng/L)43.65 ± 25.5740.41 ± 40.530.62190.72 ± 172.10189.44 ± 181.070.96< 0.01
hsCRP (mgl/L)1.90 ± 3.511.19 ± 1.640.452.58 ± 2.951.66 ± 1.680.190.54
Iron (mcmol/L)18.75 ± 6.4021.56 ± 7.720.0615.50 ± 5.8717.44 ± 6.120.260.20
Transferrin (g/L)2.82 ± 0.322.83 ± 0.360.782.18 ± 0.322.25 ± 0.370.170.23
Ferritin (mcmol/L)82.69 ± 78.9887.69 ± 73.040.55452.61 ± 1179.15291.72 ± 579.020.28< 0.01
Transferrin saturation (%)27.50 ± 11.2731.19 ± 12.580.0829.44 ± 13.1731.61 ± 11.370.480.54
ACR (mg/mmol)0.49 ± 1.350.34 ± 0.780.765.53 ± 5.465.58 ± 7.200.97< 0.01
PCR (mg/mmol)11.12 ± 5.1311.35 ± 3.820.8715.58 ± 8.8917.20 ± 10.830.360.05
  1. Legend: n number of participants, NA not applicable, M/F male/female, IHD ischaemic heart disease, eGFR estimated glomerular filtration rate, HDL high-density lipoprotein, LDL low-density lipoprotein, PTH parathyroid hormone, NT-pro-BNP N-terminal-pro-brain natriuretic peptide, hsCRP highly sensitive C-reactive protein, ACR albumin to creatinine ratio, PCR protein to creatinine ratio
  2. Data presented as mean ± standard deviation