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Table 2 All-cause death and adverse events

From: Targeting the DPP-4-GLP-1 pathway improves exercise tolerance in heart failure patients: a systematic review and meta-analysis

 

Treatment and control

Patients included in analysis

All cause death (N,)

Drug related adverse events (N)

Arturi2016

Liraglutide

10

0

0

Sitagliptin

10

0

0

Insulin glargine

12

0

0

Jorsal2016

Liraglutide

122

1

AE (cardiac = 13, gastrointestinal = 80*, CNS = 38*, other = 38(31.1%)),

SAE (cardiac = 12, gastrointestinal = 0, CNS = 2, other = 13)

Placebo

119

0

AE (cardiac = 10, gastrointestinal = 19, CNS = 15, other = 38),

SAE (cardiac = 3, gastrointestinal = 1, CNS = 3, other = 9)

Lepore2016

Albiglutide

27

0

AE = 20, SAE = 0

Placebo

30

0

AE = 25, SAE = 4

Margulies2016

Liraglutide

154

19

Cardiac = 37; glycemic = 36; other = 35

Placebo

146

16

Cardiac = 34; glycemic = 28; other = 52

  1. *means P ≤ 0.05 compared with placebo