Author, years | Study design | Patients | Intervention | |
Arturi2016 | Open-label RCT | Total 32 participants TGliraglutide: N = 10 (70% male) 59.5 ± 9 years, LVEF 41.5 ± 2.2% TGsitagliptin:N = 10 (60% male) 60.5 ± 10 years, LVEF 41.8 ± 2.6% CG: N = 12 (75% male) 60 ± 8 years LVEF 42 ± 1.5%, Of all patients, 27 with NYHA class III and 5 with NYHA class II | liraglutide 1.8 mg VS sitagliptin 100 mg VS glargine insulin | |
Jorsal2016 | Double-blinded RCT | Total 241 participates TG: N = 122 (89%male) 65 ± 9.2 years LVEF 33.7 ± 7.6% NYHA class I-III CG: N = 119(89%male) 65 ± 10.7 years LVEF35.4 ± 9.4% NYHA class I-III | liraglutide 1.8 mg VS placebo | |
Lepore2016 | Double-blinded RCT | Total 82 participates TG:N = 27 (74%male) 58 ± 10 years LVEF 31 ± 8.3% NYHA class II-III CG: N = 30 (70%male) 56 ± 10 years LVEF 32 ± 8.6% NYHA class II-III 25 participates in 3.75 mg or 15 mg was discontinued | Albiglutide 3.75 mg,15 mg,30 mg VS placebo | |
Margulies2016 | Double-blinded RCT | Total 300 participates TG:N = 154(80%male) 62 (52–68) years LVEF 25(20–33)% NYHA class II-IV CG:N = 146 (77%male) 61 (51–67) years LVEF 25 (19–32)% NYHA class II-IV | liraglutide; at 0.6 mg SQ daily for 7 days, 1.2 mg SQ daily from day 7 through day 30, 1.8 mg for the rest VS placebo | |
Author, years | Follow-up | T2DM status | Additional antidiabetic drugs | Myocardial infraction history |
Arturi2016 | 52 weeks | T2DM | Metformin or metformin and sulfonylurea | Prior acute myocardial infarction |
Jorsal2016 | 24 weeks | With or without T2DM | Any anti-diabetes drugs except GLP-1 receptor agonists, glitziness, pramlintide or any DPP-4 inhibitor within 30 days prior to randomization. Patients treat with fast-acting insulin were also excluded | Myocardial infarction within 3 months were excluded |
Lepore2016 | 12 weeks | Non-T2DM | NR | No myocardial infarction |
Margulies2016 | 180 days | With or without T2DM | Ongoing GLP-1 agonists or DDP-4 inhibitors or thiazolidinedione are not allowed. If patients treated with DDP-4, washed out for a week was permitted | NR |