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Table 1 Baseline Demographic and Clinical Characteristics of HF with LVSD Patients with and without CAD

From: Cardiovascular outcomes among elderly patients with heart failure and coronary artery disease and without atrial fibrillation: a retrospective cohort study

Baseline Characteristics of HF Patients with LVSD

Before PSM

After 1:1 PSM

CAD Cohort (N = 15,827 )

Non-CAD Cohort (N = 6,403)

  

CAD Cohort (N = 5,792 )

Non-CAD Cohort (N = 5,792)

  

N/Mean

%/SD

N/Mean

%/SD

p-value

Std

N/Mean

%/SD

N/Mean

%/SD

p-value

Std

Age (Mean)

79.8

8.3

80.9

8.7

<.0001

13.0

80.8

8.5

80.7

8.6

0.4521

1.4

Age Group

 65-74

4,849

30.6%

1,714

26.8%

<.0001

8.6

1,566

27.0%

1,573

27.2%

0.8837

0.3

 75-84

6,068

38.3%

2,296

35.9%

0.0005

5.1

2,123

36.7%

2,113

36.5%

0.8470

0.4

 85+

4,910

31.0%

2,393

37.4%

<.0001

13.4

2,103

36.3%

2,106

36.4%

0.9538

0.1

Gender

 Male

7,852

49.6%

2,278

35.6%

<.0001

28.7

2,200

38.0%

2,174

37.5%

0.6183

0.9

 Female

7,975

50.4%

4,125

64.4%

<.0001

28.7

3,592

62.0%

3,618

62.5%

0.6183

0.9

Race/Ethnicity

 White

13,636

86.2%

5,212

81.4%

<.0001

12.9

4,802

82.9%

4,787

82.6%

0.7120

0.7

 Black

1,436

9.1%

924

14.4%

<.0001

16.7

755

13.0%

760

13.1%

0.8904

0.3

 Hispanic

145

0.9%

57

0.9%

0.8535

0.3

44

0.8%

50

0.9%

0.5344

1.2

 Asian

206

1.3%

65

1.0%

0.0780

2.7

51

0.9%

63

1.1%

0.2587

2.1

 Native American

285

1.8%

110

1.7%

0.6723

0.6

112

1.9%

101

1.7%

0.4468

1.4

 Other

92

0.6%

23

0.4%

0.0366

3.2

22

0.4%

23

0.4%

0.8813

0.3

 Unknown

27

0.2%

12

0.2%

0.7861

0.4

6

0.1%

8

0.1%

0.5928

1.0

US Geographic Region

            

 Northeast

3,219

20.3%

1,271

19.9%

0.4113

1.2

1,170

20.2%

1,165

20.1%

0.9078

0.2

 Midwest

4,149

26.2%

1,641

25.6%

0.3673

1.3

1,459

25.2%

1,491

25.7%

0.4950

1.3

 South

6,370

40.2%

2,506

39.1%

0.1260

2.3

2,265

39.1%

2,284

39.4%

0.7177

0.7

 West

2,051

13.0%

970

15.1%

<.0001

6.3

882

15.2%

838

14.5%

0.2503

2.1

 Other

38

0.2%

15

0.2%

0.9357

0.1

16

0.3%

14

0.2%

0.7146

0.7

Comorbidity Indices

 Charlson Comorbidity Index

4.4

2.5

3.5

2.5

<.0001

34.5

3.7

2.1

3.7

2.6

0.1720

2.5

 CHADS2 Score

3.3

1.2

3.0

1.1

<.0001

26.8

3.1

1.1

3.1

1.1

0.5115

1.2

Comorbid Conditions

 Hypertension

12,772

80.7%

4,756

74.3%

<.0001

15.4

4,397

75.9%

4,384

75.7%

0.7779

0.5

 Hyperlipidemia

10,716

67.7%

2,993

46.7%

<.0001

43.4

2,896

50.0%

2,937

50.7%

0.4461

1.4

 Anemia

7,298

46.1%

2,862

44.7%

0.0554

2.8

2,614

45.1%

2,607

45.0%

0.8960

0.2

 Diabetes

7,320

46.3%

2,292

35.8%

<.0001

21.4

2,201

38.0%

2,179

37.6%

0.6734

0.8

 Chronic Renal Insufficiency

5,078

32.1%

1,738

27.1%

<.0001

10.8

1,670

28.8%

1,632

28.2%

0.4342

1.5

 Arrhythmia

4,804

30.4%

1,487

23.2%

<.0001

16.2

1,435

24.8%

1,424

24.6%

0.8126

0.4

 Pneumonia

3,994

25.2%

1,864

29.1%

<.0001

8.7

1,707

29.5%

1,651

28.5%

0.2515

2.1

 Trauma

4,064

25.7%

1,734

27.1%

0.0309

3.2

1,596

27.6%

1,563

27.0%

0.4912

1.3

 Malignant Neoplasm

3,533

22.3%

1,404

21.9%

0.5207

1.0

1,313

22.7%

1,273

22.0%

0.3721

1.7

 Peripheral Arterial Disease

3,663

23.1%

834

13.0%

<.0001

26.5

783

13.5%

814

14.1%

0.4035

1.6

 Chronic Obstructive Pulmonary Disease

2,576

16.3%

1,056

16.5%

0.6929

0.6

968

16.7%

962

16.6%

0.8811

0.3

 Dementia

1,725

10.9%

884

13.8%

<.0001

8.8

770

13.3%

768

13.3%

0.9563

0.1

 Anasarca

1,666

10.5%

899

14.0%

<.0001

10.7

738

12.7%

757

13.1%

0.5985

1.0

 Prior Ischemic Stroke

2,685

17.0%

696

10.9%

<.0001

17.7

701

12.1%

673

11.6%

0.4210

1.5

 Prior Transient Ischemic Attack

625

3.9%

192

3.0%

0.0006

5.2

175

3.0%

183

3.2%

0.6676

0.8

 Prior Venous Thromboembolism

912

5.8%

535

8.4%

<.0001

10.1

436

7.5%

429

7.4%

0.8046

0.5

 Prior Major Bleeding*

597

3.8%

272

4.2%

0.0973

2.4

225

3.9%

239

4.1%

0.5071

1.2

Commander Criteria

 Documented previous CAD

15,787

99.75%

0

0.00%

N/A

5,775

99.71%

0

0.00%

N/A

 History of prior Coronary Artery Bypass Graft (CABG)

933

5.89%

0

0.00%

273

4.71%

0

0.00%

 History of percutaneous coronary intervention (PCI) with or without stent

2,430

15.35%

0

0.00%

730

12.60%

0

0.00%

  1. CAD: coronary artery disease; CHADS2: congestive HF, age ≥75 years, diabetes mellitus, prior stroke, transient ischemic attack or venous thromboembolism; HF: heart failure; PSM: propensity score matching; SD: standard deviation; STD: standardized difference
  2. *Major bleeding was identified using the ICD-9-CM codes for intracranial Hemorrhage (ICD-9-CM: 430, 431, 432.0, 432.1, 432.9, 852.0x, 852.2x, 852.4x, 853.0), and extracranial hemorrhage (ICD-9-CM: 423.0, 455.2, 455.5, 455.8, 456.0, 456.20, 459.0, 530.7, 530.82, 531.0-531.6, 532.0-532.6, 533.0-533.6, 534.0-534.6, 535.01-535.61, 537.83, 562.02, 562.03, 562.12, 562.13, 568.81, 569.3, 569.85, 578.0, 578.1, 578.9, 593.81,599.7, 719.11, 784.7, 784.8, and 786.3)