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Table 1 Baseline Demographic and Clinical Characteristics of HF with LVSD Patients with and without CAD

From: Cardiovascular outcomes among elderly patients with heart failure and coronary artery disease and without atrial fibrillation: a retrospective cohort study

Baseline Characteristics of HF Patients with LVSD Before PSM After 1:1 PSM
CAD Cohort (N = 15,827 ) Non-CAD Cohort (N = 6,403)    CAD Cohort (N = 5,792 ) Non-CAD Cohort (N = 5,792)   
N/Mean %/SD N/Mean %/SD p-value Std N/Mean %/SD N/Mean %/SD p-value Std
Age (Mean) 79.8 8.3 80.9 8.7 <.0001 13.0 80.8 8.5 80.7 8.6 0.4521 1.4
Age Group
 65-74 4,849 30.6% 1,714 26.8% <.0001 8.6 1,566 27.0% 1,573 27.2% 0.8837 0.3
 75-84 6,068 38.3% 2,296 35.9% 0.0005 5.1 2,123 36.7% 2,113 36.5% 0.8470 0.4
 85+ 4,910 31.0% 2,393 37.4% <.0001 13.4 2,103 36.3% 2,106 36.4% 0.9538 0.1
Gender
 Male 7,852 49.6% 2,278 35.6% <.0001 28.7 2,200 38.0% 2,174 37.5% 0.6183 0.9
 Female 7,975 50.4% 4,125 64.4% <.0001 28.7 3,592 62.0% 3,618 62.5% 0.6183 0.9
Race/Ethnicity
 White 13,636 86.2% 5,212 81.4% <.0001 12.9 4,802 82.9% 4,787 82.6% 0.7120 0.7
 Black 1,436 9.1% 924 14.4% <.0001 16.7 755 13.0% 760 13.1% 0.8904 0.3
 Hispanic 145 0.9% 57 0.9% 0.8535 0.3 44 0.8% 50 0.9% 0.5344 1.2
 Asian 206 1.3% 65 1.0% 0.0780 2.7 51 0.9% 63 1.1% 0.2587 2.1
 Native American 285 1.8% 110 1.7% 0.6723 0.6 112 1.9% 101 1.7% 0.4468 1.4
 Other 92 0.6% 23 0.4% 0.0366 3.2 22 0.4% 23 0.4% 0.8813 0.3
 Unknown 27 0.2% 12 0.2% 0.7861 0.4 6 0.1% 8 0.1% 0.5928 1.0
US Geographic Region             
 Northeast 3,219 20.3% 1,271 19.9% 0.4113 1.2 1,170 20.2% 1,165 20.1% 0.9078 0.2
 Midwest 4,149 26.2% 1,641 25.6% 0.3673 1.3 1,459 25.2% 1,491 25.7% 0.4950 1.3
 South 6,370 40.2% 2,506 39.1% 0.1260 2.3 2,265 39.1% 2,284 39.4% 0.7177 0.7
 West 2,051 13.0% 970 15.1% <.0001 6.3 882 15.2% 838 14.5% 0.2503 2.1
 Other 38 0.2% 15 0.2% 0.9357 0.1 16 0.3% 14 0.2% 0.7146 0.7
Comorbidity Indices
 Charlson Comorbidity Index 4.4 2.5 3.5 2.5 <.0001 34.5 3.7 2.1 3.7 2.6 0.1720 2.5
 CHADS2 Score 3.3 1.2 3.0 1.1 <.0001 26.8 3.1 1.1 3.1 1.1 0.5115 1.2
Comorbid Conditions
 Hypertension 12,772 80.7% 4,756 74.3% <.0001 15.4 4,397 75.9% 4,384 75.7% 0.7779 0.5
 Hyperlipidemia 10,716 67.7% 2,993 46.7% <.0001 43.4 2,896 50.0% 2,937 50.7% 0.4461 1.4
 Anemia 7,298 46.1% 2,862 44.7% 0.0554 2.8 2,614 45.1% 2,607 45.0% 0.8960 0.2
 Diabetes 7,320 46.3% 2,292 35.8% <.0001 21.4 2,201 38.0% 2,179 37.6% 0.6734 0.8
 Chronic Renal Insufficiency 5,078 32.1% 1,738 27.1% <.0001 10.8 1,670 28.8% 1,632 28.2% 0.4342 1.5
 Arrhythmia 4,804 30.4% 1,487 23.2% <.0001 16.2 1,435 24.8% 1,424 24.6% 0.8126 0.4
 Pneumonia 3,994 25.2% 1,864 29.1% <.0001 8.7 1,707 29.5% 1,651 28.5% 0.2515 2.1
 Trauma 4,064 25.7% 1,734 27.1% 0.0309 3.2 1,596 27.6% 1,563 27.0% 0.4912 1.3
 Malignant Neoplasm 3,533 22.3% 1,404 21.9% 0.5207 1.0 1,313 22.7% 1,273 22.0% 0.3721 1.7
 Peripheral Arterial Disease 3,663 23.1% 834 13.0% <.0001 26.5 783 13.5% 814 14.1% 0.4035 1.6
 Chronic Obstructive Pulmonary Disease 2,576 16.3% 1,056 16.5% 0.6929 0.6 968 16.7% 962 16.6% 0.8811 0.3
 Dementia 1,725 10.9% 884 13.8% <.0001 8.8 770 13.3% 768 13.3% 0.9563 0.1
 Anasarca 1,666 10.5% 899 14.0% <.0001 10.7 738 12.7% 757 13.1% 0.5985 1.0
 Prior Ischemic Stroke 2,685 17.0% 696 10.9% <.0001 17.7 701 12.1% 673 11.6% 0.4210 1.5
 Prior Transient Ischemic Attack 625 3.9% 192 3.0% 0.0006 5.2 175 3.0% 183 3.2% 0.6676 0.8
 Prior Venous Thromboembolism 912 5.8% 535 8.4% <.0001 10.1 436 7.5% 429 7.4% 0.8046 0.5
 Prior Major Bleeding* 597 3.8% 272 4.2% 0.0973 2.4 225 3.9% 239 4.1% 0.5071 1.2
Commander Criteria
 Documented previous CAD 15,787 99.75% 0 0.00% N/A 5,775 99.71% 0 0.00% N/A
 History of prior Coronary Artery Bypass Graft (CABG) 933 5.89% 0 0.00% 273 4.71% 0 0.00%
 History of percutaneous coronary intervention (PCI) with or without stent 2,430 15.35% 0 0.00% 730 12.60% 0 0.00%
  1. CAD: coronary artery disease; CHADS2: congestive HF, age ≥75 years, diabetes mellitus, prior stroke, transient ischemic attack or venous thromboembolism; HF: heart failure; PSM: propensity score matching; SD: standard deviation; STD: standardized difference
  2. *Major bleeding was identified using the ICD-9-CM codes for intracranial Hemorrhage (ICD-9-CM: 430, 431, 432.0, 432.1, 432.9, 852.0x, 852.2x, 852.4x, 853.0), and extracranial hemorrhage (ICD-9-CM: 423.0, 455.2, 455.5, 455.8, 456.0, 456.20, 459.0, 530.7, 530.82, 531.0-531.6, 532.0-532.6, 533.0-533.6, 534.0-534.6, 535.01-535.61, 537.83, 562.02, 562.03, 562.12, 562.13, 568.81, 569.3, 569.85, 578.0, 578.1, 578.9, 593.81,599.7, 719.11, 784.7, 784.8, and 786.3)