Circulating microRNA-1 in the diagnosis and predicting prognosis of patients with chest pain: a prospective cohort study

Table 3 Prognostic value of miR-1 and cTnI in patients with ACP

Prognostic performance for MACEs (30 days) in patients with ACP
Biomarker	AUC (95%CI)	P value	Sen.	Spe.	PPV	NPV	LR+	LR-
miR-1	0.620 (0.500~0.740)	0.046	80.0	50.3	0.113	0.970	1.610	0.397
cTnI	0.469 (0.345~0.594)	0.612	40.0	66.5	0.086	0.933	1.192	0.903
Prognostic performance for overall mortality (720 days) in patients with ACP
Biomarker	AUC (95%CI)	P value	Sen.	Spe.	PPV	NPV	LR+	LR-
miR-1	0.666 (0.555~0.778)	0.001	47.1	86.3	0.276	0.936	3.440	0.613
cTnI	0.474 (0.359~0.589)	0.614	20.1	88.6	0.167	0.910	1.806	0.896

AUC the area under the receiver operating characteristics curve, ACP acute chest pain, miR-1 microRNA-1, cTnI Cardiac troponin I, Cl confidence interval, Sen. sensitivity (%), Spe. specificity (%), PPV positive predictive value, NPV negative predictive value, LR+ positive likelihood ratio, LR- negative likelihood ratio

ISSN: 1471-2261