Skip to main content

Table 2 Association of frequency of sleep disturbances within 4 weeks prior to AMI (categorization 1) and long-term mortality in male and female patients

From: Association of sleep disturbances within 4 weeks prior to incident acute myocardial infarction and long-term survival in male and female patients: an observational study from the MONICA/KORA Myocardial Infarction Registry

  Men (n = 2511; 318 deaths) Women (n = 828; 131 deaths)
HR [95% CI] p-valuea HR [95% CI] p-valuea
  Frequency of sleep disturbances  
Unadjusted model never 1 Ref. 0.0024 1 Ref. 0.9686
sometimes 1.58 [1.23–2.03]   1.00 [0.67–1.49]  
nightly 1.00 [0.66–1.52]   0.94 [0.59–1.51]  
Age-adjusted model never 1 Ref. 0.0032 1 Ref. 0.9773
sometimes 1.56 [1.21–2.00]   0.97 [0.65–1.44]  
nightly 1.00 [0.66–1.51]   0.96 [0.60–1.53]  
Model Lifestyleb never 1 Ref. 0.0038 1 Ref. 0.9665
sometimes 1.55 [1.20–1.99]   0.96 [0.64–1.43]  
nightly 0.99 [0.65–1.50]   0.95 [0.59–1.52]  
Model Comorbiditiesc never 1 Ref. 0.0060 1 Ref. 0.9556
sometimes 1.50 [1.16–1.93]   0.98 [0.66–1.47]  
nightly 0.92 [0.60–1.39]   0.93 [0.58–1.49]  
Model Clinicald never 1 Ref. 0.0150 1 Ref. 0.9899
sometimes 1.47 [1.14–1.89]   0.97 [0.65–1.46]  
nightly 1.02 [0.67–1.54]   0.97 [0.61–1.57]  
Full modele never 1 Ref. 0.0370 1 Ref. 0.9055
sometimes 1.40 [1.08–1.81]   0.99 [0.66–1.49]  
nightly 0.95 [0.62–1.45]   0.90 [0.55–1.46]  
  1. AMI = acute myocardial infarction, CI = confidence interval, HR = Hazard Ratio
  2. ap-value obtained from Likelihood-Ratio test for overall significance of 3-categorical variable ‘frequency of sleep disturbances’ in the respective model
  3. bMEN: adjusted for age (cont.), married, low education (< 9 years), employment status, smoking ever and BMI (cont)
  4. WOMEN: adjusted for age (cont.), married and employment status
  5. cMEN: adjusted for age (cont.), hypertension, angina, diabetes, dyslipidemia and stroke
  6. WOMEN: adjusted for age, diabetes and stroke
  7. dMEN: adjusted for age (cont.), type of infarction, any revascularization treatment (coronary artery bypass surgery, percutaneous coronary intervention (PCI) with/without stenting, or thrombolysis), all four evidence based medications at discharge (antiplatelet agents, beta-blockers, ACEIs/ARBs (Angiotensin-converting enzyme inhibitors/Angiotensin receptor blockers), statins) and year of MI
  8. WOMEN: adjusted for age (cont.), type of infarction, any revascularization treatment and all four evidence based medications at discharge
  9. eMEN AND WOMEN: adjusted for age (cont.), low education (< 9 years), married, employment status, ever smoking, BMI (cont.), hypertension, angina, diabetes, dyslipidemia, stroke, type of infarction, any revascularization treatment, all four evidence based medications at discharge and year of MI